TLR10 and F8A1

Data Source:
HPRD (two hybrid)

		TLR10	F8A1
Description		toll like receptor 10	coagulation factor VIII associated 1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane	Nucleus Early Endosome Nuclear Body
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating	Molecular_function Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Toll-like Receptor 10 Signaling Pathway Innate Immune Response Positive Regulation Of Inflammatory Response	Vesicle Cytoskeletal Trafficking Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways		Toll Like Receptor 10 (TLR10) Cascade IRAK4 deficiency (TLR5) MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Asthma ( 31361310 31959851 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Helicobacter pylori serologic status ( 23652523) Limited cutaneous systemic scleroderma ( 29293537) Self-reported allergy ( 23817569) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)
Interacting Genes		12 interacting genes: CAT ECH1 F8A1 FLNA FUT7 GLDC LUC7L3 MYD88 PTPN6 TLR1 TLR2 TRIM54	6 interacting genes: DNMT3A HTT MTNR1A SH3GLB1 SNTA1 TLR10
Entrez ID		81793	8263
HPRD ID		05884	02374
Ensembl ID		ENSG00000174123	ENSG00000277203
Uniprot IDs		A0A024R9W4 Q9BXR5	P23610
PDB IDs		2J67	6EZ8 6X9O
Enriched GO Terms of Interacting Partners?
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