ECH1 and TIMP1

Data Source:
HPRD (two hybrid)

		ECH1	TIMP1
Description		enoyl-CoA hydratase 1	TIMP metallopeptidase inhibitor 1
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GO Annotations	Cellular Component	Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Membrane Extracellular Exosome	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome
	Molecular Function	Protein Binding Delta3,5-delta2,4-dienoyl-CoA Isomerase Activity	Protease Binding Cytokine Activity Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Zinc Ion Binding Peptidase Inhibitor Activity
	Biological Process	Protein Targeting To Peroxisome Fatty Acid Beta-oxidation	Cell Activation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Platelet Degranulation Aging Positive Regulation Of Cell Population Proliferation Response To Hormone Response To Organic Substance Negative Regulation Of Endopeptidase Activity Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Response To Cytokine Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Response To Peptide Hormone Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Membrane Protein Ectodomain Proteolysis Cartilage Development Cellular Response To UV-A Negative Regulation Of Trophoblast Cell Migration Negative Regulation Of Metallopeptidase Activity Regulation Of Integrin-mediated Signaling Pathway
Pathways		Peroxisomal protein import Peroxisomal protein import	Platelet degranulation Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Logical memory (immediate recall) in mild cognitive impairment ( 29274321)
Interacting Genes		11 interacting genes: APP CSTF2 EEF1D EEF1G FAM9B HTT PAFAH1B3 SERPINB9 STAT3 TIMP1 TLR10	8 interacting genes: CD63 ECH1 EEF1B2 MMP1 MMP2 MMP3 MYOC RECQL5
Entrez ID		1891	7076
HPRD ID		02825	02371
Ensembl ID		ENSG00000104823	ENSG00000102265
Uniprot IDs		A0A384MR44 Q13011	B4DJK3 P01033 Q6FGX5
PDB IDs		2VRE	1D2B 1LQN 1OO9 1UEA 2J0T 3MA2 3V96 6MAV 6N9D
Enriched GO Terms of Interacting Partners?
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