TMX1 and GET3

Data Source:
BioGRID (two hybrid)

		TMX1	GET3
Description		thioredoxin related transmembrane protein 1	guided entry of tail-anchored proteins factor 3, ATPase
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Membrane GET Complex Extracellular Exosome
	Molecular Function	Protein Binding Disulfide Oxidoreductase Activity	Protein Binding ATP Binding Arsenite Transmembrane Transporter Activity ATPase Activity Metal Ion Binding
	Biological Process	Response To Endoplasmic Reticulum Stress	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Arsenite Transport IRE1-mediated Unfolded Protein Response Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways			Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs			ATP
Diseases
GWAS		Cancer ( 29299148) Nonsyndromic cleft lip with or without cleft palate ( 28087736) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576)
Interacting Genes		12 interacting genes: BCL2L2 CCR1 CDC42 FAS FKBP8 GET3 GIMAP1 GIMAP5 LHFPL5 PMP22 SPI1 SULT2A1	41 interacting genes: AGR2 APLN ASPH CACNA1A CAMLG CREB3L4 EMSY FAM209A FKBP7 GET4 GOLM1 GPX7 GPX8 HILPDA IGFBP6 KCNE4 KCNE5 LDLRAD4 PDIA6 PEX14 PFDN1 PGRMC1 PGRMC2 PRB3 PRR4 RHEX SEC61A1 SEC61B SMIM19 SPP1 STATH STX5 SYPL2 TK1 TMEM154 TMEM51 TMX1 TTR VAMP2 VWC2 WFDC3
Entrez ID		81542	439
HPRD ID		15590	03555
Ensembl ID		ENSG00000139921	ENSG00000198356
Uniprot IDs		Q9H3N1	O43681
PDB IDs		1X5E	6SO5
Enriched GO Terms of Interacting Partners?
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