TMX1 and FKBP8

Data Source:
BioGRID (two hybrid, proximity labelling technology)

		TMX1	FKBP8
Description		thioredoxin related transmembrane protein 1	FKBP prolyl isomerase 8
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Mitochondrion Endoplasmic Reticulum Cytosol Membrane Integral Component Of Endoplasmic Reticulum Membrane Mitochondrial Membrane Protein-containing Complex
	Molecular Function	Protein Binding Disulfide Oxidoreductase Activity	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Identical Protein Binding Protein Folding Chaperone Metal Ion Binding Disordered Domain Specific Binding
	Biological Process	Response To Endoplasmic Reticulum Stress	Protein Peptidyl-prolyl Isomerization Cell Fate Specification Negative Regulation Of Protein Phosphorylation Protein Folding Apoptotic Process Smoothened Signaling Pathway Regulation Of Gene Expression Viral Process Dorsal/ventral Neural Tube Patterning Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intracellular Signal Transduction Camera-type Eye Development Negative Regulation Of Apoptotic Process
Pathways			Ub-specific processing proteases
Drugs
Diseases
GWAS		Cancer ( 29299148) Nonsyndromic cleft lip with or without cleft palate ( 28087736) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576)	Plasma parathyroid hormone levels ( 30134803) Urinary potassium excretion ( 31409800)
Interacting Genes		12 interacting genes: BCL2L2 CCR1 CDC42 FAS FKBP8 GET3 GIMAP1 GIMAP5 LHFPL5 PMP22 SPI1 SULT2A1	48 interacting genes: ANKMY2 ARHGEF5 ARL13B ATP13A2 BCL2 BCL2L1 BNIPL CD79A CIDEB CLCN1 CXCR2 CYB561 CYBRD1 EBP EGFR ELOVL4 ERBB2 ERGIC3 FAM174A FGF14 GPR37 JAGN1 MAPK14 MFSD14B MTOR PEX12 PLN PPP3CA PSMC1 PSMD2 RETREG3 RHBDD2 RHEB SCN3B SLC10A6 SLC35A5 SLC35B1 SMO TERF1 TMEM14B TMEM254 TMEM31 TMEM43 TMEM45B TMEM80 TMX1 VHL ZFPL1
Entrez ID		81542	23770
HPRD ID		15590	05327
Ensembl ID		ENSG00000139921	ENSG00000105701
Uniprot IDs		Q9H3N1	A0A024R7P2 B2R8G6 Q14318
PDB IDs		1X5E	2AWG 2D9F 2F2D 2MF9 3EY6 5MGX
Enriched GO Terms of Interacting Partners?
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