GET3 and PDIA6

Data Source:
BioGRID (two hybrid)

		GET3	PDIA6
Description		guided entry of tail-anchored proteins factor 3, ATPase	protein disulfide isomerase family A member 6
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Membrane GET Complex Extracellular Exosome	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Exosome
	Molecular Function	Protein Binding ATP Binding Arsenite Transmembrane Transporter Activity ATPase Activity Metal Ion Binding	Protein Disulfide Isomerase Activity Protein Binding Peptide Disulfide Oxidoreductase Activity
	Biological Process	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Arsenite Transport IRE1-mediated Unfolded Protein Response Tail-anchored Membrane Protein Insertion Into ER Membrane	Protein Folding Protein Phosphopantetheinylation IRE1-mediated Unfolded Protein Response Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		ATP
Diseases
GWAS			Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690)
Interacting Genes		41 interacting genes: AGR2 APLN ASPH CACNA1A CAMLG CREB3L4 EMSY FAM209A FKBP7 GET4 GOLM1 GPX7 GPX8 HILPDA IGFBP6 KCNE4 KCNE5 LDLRAD4 PDIA6 PEX14 PFDN1 PGRMC1 PGRMC2 PRB3 PRR4 RHEX SEC61A1 SEC61B SMIM19 SPP1 STATH STX5 SYPL2 TK1 TMEM154 TMEM51 TMX1 TTR VAMP2 VWC2 WFDC3	17 interacting genes: ATP13A2 CASP8 CLN8 CSNK2A1 GET3 LGALS9 LINC01554 MC4R MTNR1A MTNR1B SGTB SLC22A2 SLC2A4 SUMO4 TRIM14 UBE3A VKORC1
Entrez ID		439	10130
HPRD ID		03555	07504
Ensembl ID		ENSG00000198356	ENSG00000143870
Uniprot IDs		O43681	A0A384NPU5 Q15084
PDB IDs		6SO5	1X5D 3VWW 3W8J 4EF0 4GWR
Enriched GO Terms of Interacting Partners?
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