POLR2M and APOD

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		POLR2M	APOD
Description		RNA polymerase II subunit M	apolipoprotein D
Image
GO Annotations	Cellular Component	Intracellular Anatomical Structure Nuclear Envelope RNA Polymerase II, Core Complex RNA Polymerase II, Holoenzyme Neuronal Cell Body	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Cytosolic Ribosome Dendrite Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	DNA-directed 5'-3' RNA Polymerase Activity	Lipid Transporter Activity Protein Binding Cholesterol Binding
	Biological Process	RNA Biosynthetic Process Intracellular Signal Transduction Maintenance Of ER Location	Response To Reactive Oxygen Species Angiogenesis Glucose Metabolic Process Lipid Metabolic Process Lipid Transport Brain Development Aging Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peripheral Nervous System Axon Regeneration Tissue Regeneration Negative Regulation Of Protein Import Into Nucleus Response To Drug Negative Regulation Of Smooth Muscle Cell Proliferation Response To Axon Injury Negative Regulation Of Focal Adhesion Assembly Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of T Cell Migration
Pathways			Transport of fatty acids NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs			Vitamin A Copper
Diseases
GWAS		Body mass index ( 28552196) Seasonality ( 25562672)	HDL cholesterol levels ( 32203549)
Interacting Genes		22 interacting genes: AHSP ANKHD1 APOD CEBPG CEP126 DAPK1 DGKZ HIGD1B LRRK1 LRRK2 MYO3A MYO9A NEDD4 PSMC2 RBM4B RPL7A SCMH1 SIVA1 THAP1 UQCRQ WDR89 ZNF410	51 interacting genes: AIG1 APH1A APOA2 AQP9 ATP6V0B ATP6V0E1 BCL2L13 BIK CD53 CD79A CLDN7 CLEC10A CPLX4 CREB3 CREB3L1 ERGIC3 EVI2B FAM209A FFAR2 FKBP7 FPR2 GDAP1 GJA8 GORAB GPR151 GPR42 GPX8 KCNJ6 KIR2DL3 LEPR LMNA MFF MGST3 MTERF2 MTIF3 NCAPH2 PDZK1IP1 POLR2M RHBDL1 SHBG SIGLECL1 SLC10A6 SLC35C2 TEX29 TMEM237 TMEM31 TMEM45B TMEM52B TMEM79 VAPA VSIR
Entrez ID		81488	347
HPRD ID		07575	00134
Ensembl ID		ENSG00000255529	ENSG00000189058
Uniprot IDs		P0CAP1 P0CAP2 Q6EEV4	P05090
PDB IDs		2KXS 6DRD	2APD 2HZQ 2HZR
Enriched GO Terms of Interacting Partners?
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