POLR2M and PSMC2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		POLR2M	PSMC2
Description		RNA polymerase II subunit M	proteasome 26S subunit, ATPase 2
Image
GO Annotations	Cellular Component	Intracellular Anatomical Structure Nuclear Envelope RNA Polymerase II, Core Complex RNA Polymerase II, Holoenzyme Neuronal Cell Body	Proteasome Complex P-body Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle, Base Subcomplex Membrane Proteasome Accessory Complex Secretory Granule Lumen Cytoplasmic Ribonucleoprotein Granule Dendritic Spine Ficolin-1-rich Granule Lumen
	Molecular Function	DNA-directed 5'-3' RNA Polymerase Activity	Protein Binding ATP Binding ATPase Activity TBP-class Protein Binding Proteasome-activating ATPase Activity
	Biological Process	RNA Biosynthetic Process Intracellular Signal Transduction Maintenance Of ER Location	MAPK Cascade Protein Polyubiquitination Osteoblast Differentiation Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Deubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neutrophil Degranulation Regulation Of MRNA Stability Post-translational Protein Modification Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly T Cell Receptor Signaling Pathway Transmembrane Transport Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Hematopoietic Stem Cell Differentiation
Pathways			Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Neutrophil degranulation CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 28552196) Seasonality ( 25562672)
Interacting Genes		22 interacting genes: AHSP ANKHD1 APOD CEBPG CEP126 DAPK1 DGKZ HIGD1B LRRK1 LRRK2 MYO3A MYO9A NEDD4 PSMC2 RBM4B RPL7A SCMH1 SIVA1 THAP1 UQCRQ WDR89 ZNF410	25 interacting genes: CDKN1A CEP55 CNOT7 GTF2B GTF2F1 GTF2H1 NDC80 NDRG1 POLR2M PRKN PSMC1 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD2 PSMD5 RAD23B SKIL SUMO4 TBP TRAF6 TRIM5 UBC
Entrez ID		81488	5701
HPRD ID		07575	01105
Ensembl ID		ENSG00000255529	ENSG00000161057
Uniprot IDs		P0CAP1 P0CAP2 Q6EEV4	A0A140VK70 B7Z571 P35998
PDB IDs		2KXS 6DRD	5GJQ 5GJR 5L4G 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 5VHS 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN
Enriched GO Terms of Interacting Partners?
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