SH3BP5L and CEP57

Data Source:
BioGRID (two hybrid)

		SH3BP5L	CEP57
Description		SH3 binding domain protein 5 like	centrosomal protein 57
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Golgi Apparatus Centrosome Cytosol Microtubule
	Molecular Function	Protein Kinase Inhibitor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding Microtubule Binding Fibroblast Growth Factor Binding Protein Homodimerization Activity Gamma-tubulin Binding
	Biological Process	Intracellular Signal Transduction Negative Regulation Of Protein Tyrosine Kinase Activity	G2/M Transition Of Mitotic Cell Cycle Spermatid Development Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Microtubule Anchoring Protein Homooligomerization Ciliary Basal Body-plasma Membrane Docking
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Lead levels ( 26025379)	Cognitive ability (MTAG) ( 29186694) Erosive tooth wear (severe vs non-severe) ( 29898447) Feeling worry ( 29500382) Intelligence (MTAG) ( 29326435) Rheumatoid arthritis ( 30423114 24390342) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		10 interacting genes: CEP57 EMC2 FAM161B NINL PLEKHA5 RAB11B RAB14 RAB25 SUOX YWHAG	47 interacting genes: AARD ABI2 APP ATPAF2 CCDC136 CCDC138 CCDC185 CCHCR1 CEP63 DEUP1 DISC1 FBXL3 FGF2 GCC1 HSF2BP KDM1A KLC4 KRT13 KRT15 KRT31 KRT4 KRT40 KRT75 KRT8 KRT83 KRT86 LMO3 MAGEA2 MAGEA2B MEGF10 MIA2 MYC OIP5 PKN1 PPP1R13B RABEP1 RALBP1 RASSF10 SH3BP5L SPDEF TEX12 TFIP11 TSGA10 TSPYL4 TXLNA TXLNB UIMC1
Entrez ID		80851	9702
HPRD ID		13887	16261
Ensembl ID		ENSG00000175137	ENSG00000166037
Uniprot IDs		A0A024R0T2 Q7L8J4	Q86XR8
PDB IDs			4L0R
Enriched GO Terms of Interacting Partners?
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