CEP57 and TEX12

Data Source:
BioGRID (two hybrid)

		CEP57	TEX12
Description		centrosomal protein 57	testis expressed 12
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GO Annotations	Cellular Component	Nucleus Golgi Apparatus Centrosome Cytosol Microtubule	Central Element Chromosome
	Molecular Function	Protein Binding Microtubule Binding Fibroblast Growth Factor Binding Protein Homodimerization Activity Gamma-tubulin Binding	Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Spermatid Development Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Microtubule Anchoring Protein Homooligomerization Ciliary Basal Body-plasma Membrane Docking	Meiotic DNA Repair Synthesis Synaptonemal Complex Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Meiotic synapsis
Drugs
Diseases
GWAS		Cognitive ability (MTAG) ( 29186694) Erosive tooth wear (severe vs non-severe) ( 29898447) Feeling worry ( 29500382) Intelligence (MTAG) ( 29326435) Rheumatoid arthritis ( 30423114 24390342) Triglyceride levels x loop diuretics use interaction ( 31806883)	Inflammatory biomarkers ( 24182552)
Interacting Genes		47 interacting genes: AARD ABI2 APP ATPAF2 CCDC136 CCDC138 CCDC185 CCHCR1 CEP63 DEUP1 DISC1 FBXL3 FGF2 GCC1 HSF2BP KDM1A KLC4 KRT13 KRT15 KRT31 KRT4 KRT40 KRT75 KRT8 KRT83 KRT86 LMO3 MAGEA2 MAGEA2B MEGF10 MIA2 MYC OIP5 PKN1 PPP1R13B RABEP1 RALBP1 RASSF10 SH3BP5L SPDEF TEX12 TFIP11 TSGA10 TSPYL4 TXLNA TXLNB UIMC1	19 interacting genes: AIMP2 AP2B1 CCNC CEP57 COX5B FAM161B FAM9C INCA1 LENG1 MESD MSGN1 NUP54 OIP5 PPP1R13B SGF29 SMARCE1 SUOX SYCE2 ZNF835
Entrez ID		9702	56158
HPRD ID		16261	12045
Ensembl ID		ENSG00000166037	ENSG00000150783
Uniprot IDs		Q86XR8	A0A024R3E7 Q9BXU0
PDB IDs		4L0R	6HK8 6HK9 6R17 6R2F
Enriched GO Terms of Interacting Partners?
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