KMT2D and SMAD9

Data Source:
HPRD (two hybrid)

		KMT2D	SMAD9
Description		lysine methyltransferase 2D	SMAD family member 9
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol SMAD Protein Complex Heteromeric SMAD Protein Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Coactivator Activity Protein Binding Histone Binding Histone Methyltransferase Activity (H3-K4 Specific) Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding I-SMAD Binding
	Biological Process	Oocyte Growth Chromatin Silencing Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Estrogen Histone H3-K4 Dimethylation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Oogenesis Histone H3-K4 Methylation Histone H3-K4 Trimethylation Histone H3-K4 Monomethylation Beta-catenin-TCF Complex Assembly	Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Anatomical Structure Morphogenesis Cell Differentiation BMP Signaling Pathway SMAD Protein Signal Transduction Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways		Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Signaling by BMP
Drugs
Diseases		Kabuki syndrome
GWAS		Chronotype ( 30696823) General cognitive ability ( 29844566) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435)	Coronary artery disease ( 29212778) Heel bone mineral density ( 30598549 28869591) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407) Spontaneous preterm birth (preterm birth) ( 25599974) Total body bone mineral density ( 29304378)
Interacting Genes		10 interacting genes: AKT1 ASH2L CTNNB1 ESR1 H3C14 H4C1 MEN1 POLR2A SMAD1 SMAD9	117 interacting genes: ABTB1 ACTB ACVR1 AFF1 AP2A1 ARHGAP9 ARID1B ARNT ASB2 ASH2L BAZ1A BTG2 CAMSAP1 CEP135 CHPF CLPB CPXM2 CSH1 CSH2 CTR9 CXXC5 CYP11A1 DIAPH3 DKK1 DNAJA3 DNAJC7 DST DSTN E4F1 EIF3C EIF3E EIF3F ERVV-1 EVC2 EXPH5 FLI1 FN1 FTL GRN HEY1 HEYL HUWE1 KDM1A KDM6A KMT2D LEMD3 LMO4 LNPEP LRP5 MACO1 MAN1A2 MAN1C1 MAN2B1 MBD1 MCM3AP METAP1 MGAT1 MTMR10 MTMR11 NAGK OTUB1 PABPC4 PAPPA PELP1 PHKA2 PIR PKP2 PLEC PNPLA2 PPARD PPP2R5E PRMT6 PSAP PSMD8 QARS1 RANBP9 RFX1 RMND5A RNF123 RRBP1 RUBCN SECISBP2 SF3B1 SIL1 SMAD2 SMAD3 SMAD4 SMG1 SNRNP70 SPTBN1 STAG1 SVEP1 TBCD TERF1 TINAGL1 TOB1 TRIM29 TRIP12 TTC37 TWNK UBA6 UBE3A UBQLN1 UBQLN4 UNC45A VCPIP1 VPS8 XAB2 YWHAQ ZEB2 ZNF484 ZNF557 ZNF587 ZNF587B ZNF592 ZNF83 ZSCAN4
Entrez ID		8085	4093
HPRD ID		03664	04484
Ensembl ID		ENSG00000167548	ENSG00000120693
Uniprot IDs		O14686 Q59FG6 Q6PIA1	A0A024RDR3 O15198
PDB IDs		3UVK 4ERQ 4Z4P 6O7G	6FZT
Enriched GO Terms of Interacting Partners?
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