CUL5 and COPS6

Data Source:
HPRD (in vitro)

		CUL5	COPS6
Description		cullin 5	COP9 signalosome subunit 6
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GO Annotations	Cellular Component	Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Site Of DNA Damage	Nucleoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Calcium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity	Protein Binding Metallopeptidase Activity Isopeptidase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process ERBB2 Signaling Pathway Post-translational Protein Modification Calcium Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair Viral Process Post-translational Protein Modification
Pathways		Vif-mediated degradation of APOBEC3G Downregulation of ERBB2 signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Brain morphology (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		36 interacting genes: ANAPC11 ASB11 CCNB1IP1 CCNDBP1 COG6 COMMD1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 DCUN1D1 DEPTOR ELOA ERCC6 GHR GOLGA2 GPS1 KANK4 PRKACA PTPN5 RBX1 RHOBTB1 RHOBTB2 RHOU RNF7 SMAD2 SMURF1 SOX30 TGFBR1 TRAF6 UBC UBE2F VHL	93 interacting genes: ANXA1 ANXA7 ASH2L BFSP2 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCBE1 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS7B COPS8 COPS9 COX17 COX5A CRELD1 CUL1 CUL5 DIS3L2 DLEU1 EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 LAMA4 LPL MAP3K1 MAP7D1 MAPK1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SHC3 SLC2A1 SMN1 SNRPG STK40 STX5 SULT1E1 TDGF1 TK1 TP53 TP63 TRDMT1 TRIB3 USHBP1 VIM WIPI2 ZEB2 ZFHX3 ZNF24
Entrez ID		8065	10980
HPRD ID		03444	16735
Ensembl ID		ENSG00000166266	ENSG00000168090
Uniprot IDs		Q93034	Q7L5N1
PDB IDs		3DPL 3DQV 4JGH 4N9F 6V9I	4D10 4D18 4QFT 4R14 4WSN 6R6H 6R7F 6R7H 6R7I
Enriched GO Terms of Interacting Partners?
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