CUL5 and RHOBTB2

Data Source:
BioGRID (two hybrid)

		CUL5	RHOBTB2
Description		cullin 5	Rho related BTB domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Site Of DNA Damage	Cytosol Cytoskeleton Plasma Membrane Cell Cortex Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin-protein Transferase Activity Calcium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process ERBB2 Signaling Pathway Post-translational Protein Modification Calcium Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Engulfment Of Apoptotic Cell Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Vif-mediated degradation of APOBEC3G Downregulation of ERBB2 signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation	RHOBTB2 GTPase cycle
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Alzheimer's disease progression score ( 29860282) Height ( 28552196) Plasma trimethylamine N-oxide levels ( 28439531) Renal cell carcinoma ( 28598434) Survival in breast cancer (estrogen-receptor positive) ( 29423119)
Interacting Genes		36 interacting genes: ANAPC11 ASB11 CCNB1IP1 CCNDBP1 COG6 COMMD1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 DCUN1D1 DEPTOR ELOA ERCC6 GHR GOLGA2 GPS1 KANK4 PRKACA PTPN5 RBX1 RHOBTB1 RHOBTB2 RHOU RNF7 SMAD2 SMURF1 SOX30 TGFBR1 TRAF6 UBC UBE2F VHL	12 interacting genes: BAG4 CHEK2 CUL5 ERBB2 FGFR2 HSP90AA1 HSP90AB1 PALB2 PPM1D PTPN1 RHOBTB3 STK11
Entrez ID		8065	23221
HPRD ID		03444	06300
Ensembl ID		ENSG00000166266	ENSG00000008853
Uniprot IDs		Q93034	Q9BYZ6
PDB IDs		3DPL 3DQV 4JGH 4N9F 6V9I
Enriched GO Terms of Interacting Partners?
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