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CUL5 and VHL
Data Source:
BioGRID
(pull down)
CUL5
VHL
Description
cullin 5
von Hippel-Lindau tumor suppressor
Image
GO Annotations
Cellular Component
Cytosol
SCF Ubiquitin Ligase Complex
Cullin-RING Ubiquitin Ligase Complex
Cul5-RING Ubiquitin Ligase Complex
Site Of DNA Damage
Nucleus
Nucleoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Membrane
Molecular Function
Ubiquitin-protein Transferase Activity
Calcium Channel Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Ubiquitin Ligase-substrate Adaptor Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Viral Process
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
ERBB2 Signaling Pathway
Post-translational Protein Modification
Calcium Ion Transmembrane Transport
Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Cell Morphogenesis
Regulation Of Transcription, DNA-templated
Proteolysis
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Gene Expression
Protein Ubiquitination
Negative Regulation Of Apoptotic Process
Post-translational Protein Modification
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Protein Stabilization
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Pathways
Vif-mediated degradation of APOBEC3G
Downregulation of ERBB2 signaling
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
SUMOylation of ubiquitinylation proteins
Neddylation
Replication of the SARS-CoV-1 genome
Replication of the SARS-CoV-2 genome
RHOBTB3 ATPase cycle
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Renal cell carcinoma
von Hippel-Lindau syndrome
Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS
Refractive error (
32231278
)
Interacting Genes
36 interacting genes:
ANAPC11
ASB11
CCNB1IP1
CCNDBP1
COG6
COMMD1
COPS2
COPS3
COPS4
COPS5
COPS6
COPS7A
COPS8
DCUN1D1
DEPTOR
ELOA
ERCC6
GHR
GOLGA2
GPS1
KANK4
PRKACA
PTPN5
RBX1
RHOBTB1
RHOBTB2
RHOU
RNF7
SMAD2
SMURF1
SOX30
TGFBR1
TRAF6
UBC
UBE2F
VHL
107 interacting genes:
ACTB
AKT1
APP
AR
AURKA
CAPN7
CAPZB
CASR
CBR1
CBX1
CBX3
CCNC
CCT3
CD44
CDC34
CDKN2A
CERKL
CHEK2
CLU
COL4A2
CSNK2A1
CUL2
CUL5
DGKI
DNAJA3
DVL2
E2F1
EEF1B2
EGLN1
ELOB
ELOC
EPAS1
EPOR
FKBP8
FLNA
FN1
GHET1
GPS1
H1-2
H2BC13
H4-16
HDAC1
HDAC2
HDAC3
HIF1A
HIF1AN
HIF3A
HNRNPA2B1
HNRNPD
HSF2BP
HSPA5
HSPA8
IKBKB
JADE1
KIF2C
KIF3A
KLF4
LANCL1
MAP1LC3B
MDFI
NCL
NR4A1
NR4A2
NR4A3
PDCD5
PIAS4
PLD1
PLD2
POLR2G
PPP5C
PRDX1
PRKCI
PRMT1
PRMT8
PSMC3
RB1CC1
RBPMS
RBPMS2
RBX1
RHOBTB3
RNF139
RPL21
RPL5
RPS15A
RWDD3
SARNP
SAT2
SKP2
SLC2A1
SLC3A2
SON
SP1
TPT1
TRIM28
UBE2D1
UBE2D2
UBE2I
UBE2S
USP20
USP33
USP9X
UXT
VAPB
VBP1
YY1AP1
ZNF197
ZNF512B
Entrez ID
8065
7428
HPRD ID
03444
01905
Ensembl ID
ENSG00000166266
ENSG00000134086
Uniprot IDs
Q93034
A0A024R2F2
A0A0S2Z4K1
P40337
PDB IDs
3DPL
3DQV
4JGH
4N9F
6V9I
1LM8
1LQB
1VCB
3ZRC
3ZRF
3ZTC
3ZTD
3ZUN
4AJY
4AWJ
4B95
4B9K
4BKS
4BKT
4W9C
4W9D
4W9E
4W9F
4W9G
4W9H
4W9I
4W9J
4W9K
4W9L
4WQO
5LLI
5N4W
5NVV
5NVW
5NVX
5NVY
5NVZ
5NW0
5NW1
5NW2
5T35
6BVB
6FMI
6FMJ
6FMK
6GFX
6GFY
6GFZ
6GMN
6GMQ
6GMR
6GMX
6HAX
6HAY
6HR2
6I7Q
6I7R
6R6H
6R7F
6SIS
6ZHC
Enriched GO Terms of Interacting Partners
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