PDCD1LG2 and PDCD1

Data Source:
BioGRID (pull down)

		PDCD1LG2	PDCD1
Description		programmed cell death 1 ligand 2	programmed cell death 1
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Endomembrane System Integral Component Of Membrane	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Molecular_function Protein Binding	Protein Binding
	Biological Process	Adaptive Immune Response Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Negative Regulation Of Activated T Cell Proliferation Cellular Response To Lipopolysaccharide	Adaptive Immune Response Apoptotic Process Humoral Immune Response Multicellular Organism Development T Cell Costimulation Regulation Of Immune Response Negative Regulation Of Immune Response Positive Regulation Of T Cell Apoptotic Process
Pathways		PD-1 signaling	PD-1 signaling Potential therapeutics for SARS
Drugs			CT-011 Nivolumab Pembrolizumab Cemiplimab Camrelizumab Spartalizumab Tislelizumab Toripalimab Dostarlimab Sintilimab Retifanlimab AMP-224 MEDI0680
Diseases			Systemic lupus erythematosus
GWAS		Blood protein levels ( 30072576 29875488 28240269)	Crohn's disease ( 26192919) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494)
Interacting Genes		20 interacting genes: ATP6V0C ERMP1 GALNT15 GPR37L1 KTN1 LRP10 MFSD6 PDCD1 RUSF1 SLC35C2 SLC38A1 SLC38A7 SLC41A2 SLC7A1 SMIM3 TAS2R10 TMEM147 TMEM218 TMEM239 TMEM97	2 interacting genes: CD274 PDCD1LG2
Entrez ID		80380	5133
HPRD ID		16147	02590
Ensembl ID		ENSG00000197646	ENSG00000188389
Uniprot IDs		Q9BQ51	A0A0M3M0G7 Q15116
PDB IDs		6UMT	2M2D 3RRQ 4ZQK 5B8C 5GGR 5GGS 5IUS 5JXE 5WT9 6HIG 6J14 6J15 6JBT 6JJP 6K0Y 6R5G 6ROY 6ROZ 6UMT 6UMU 6UMV 6XKR 7BXA 7CU5
Enriched GO Terms of Interacting Partners?
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