PDCD1 and PDCD1LG2

Data Source:
BioGRID (pull down)

		PDCD1	PDCD1LG2
Description		programmed cell death 1	programmed cell death 1 ligand 2
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Endomembrane System Integral Component Of Membrane
	Molecular Function	Protein Binding	Molecular_function Protein Binding
	Biological Process	Adaptive Immune Response Apoptotic Process Humoral Immune Response Multicellular Organism Development T Cell Costimulation Regulation Of Immune Response Negative Regulation Of Immune Response Positive Regulation Of T Cell Apoptotic Process	Adaptive Immune Response Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Negative Regulation Of Activated T Cell Proliferation Cellular Response To Lipopolysaccharide
Pathways		PD-1 signaling Potential therapeutics for SARS	PD-1 signaling
Drugs		CT-011 Nivolumab Pembrolizumab Cemiplimab Camrelizumab Spartalizumab Tislelizumab Toripalimab Dostarlimab Sintilimab Retifanlimab AMP-224 MEDI0680
Diseases		Systemic lupus erythematosus
GWAS		Crohn's disease ( 26192919) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494)	Blood protein levels ( 30072576 29875488 28240269)
Interacting Genes		2 interacting genes: CD274 PDCD1LG2	20 interacting genes: ATP6V0C ERMP1 GALNT15 GPR37L1 KTN1 LRP10 MFSD6 PDCD1 RUSF1 SLC35C2 SLC38A1 SLC38A7 SLC41A2 SLC7A1 SMIM3 TAS2R10 TMEM147 TMEM218 TMEM239 TMEM97
Entrez ID		5133	80380
HPRD ID		02590	16147
Ensembl ID		ENSG00000188389	ENSG00000197646
Uniprot IDs		A0A0M3M0G7 Q15116	Q9BQ51
PDB IDs		2M2D 3RRQ 4ZQK 5B8C 5GGR 5GGS 5IUS 5JXE 5WT9 6HIG 6J14 6J15 6JBT 6JJP 6K0Y 6R5G 6ROY 6ROZ 6UMT 6UMU 6UMV 6XKR 7BXA 7CU5	6UMT
Enriched GO Terms of Interacting Partners?
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