SLX1A and MUS81

Data Source:
BioGRID (pull down)

		SLX1A	MUS81
Description		SLX1 homolog A, structure-specific endonuclease subunit	MUS81 structure-specific endonuclease subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Slx1-Slx4 Complex	Nucleus Nucleoplasm Nucleolus Holliday Junction Resolvase Complex
	Molecular Function	Protein Binding Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity Metal Ion Binding	DNA Binding Protein Binding Metal Ion Binding 3'-flap Endonuclease Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Maintenance Via Telomere Lengthening Interstrand Cross-link Repair Telomeric D-loop Disassembly Nucleic Acid Phosphodiester Bond Hydrolysis T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Break-induced Replication DNA Catabolic Process, Endonucleolytic DNA Repair Intra-S DNA Damage Checkpoint Osteoblast Proliferation Interstrand Cross-link Repair Response To Intra-S DNA Damage Checkpoint Signaling
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Acne (severe) ( 24927181) Breast cancer ( 23535729)
Interacting Genes		6 interacting genes: EME1 ERCC1 ERCC4 GRB2 MUS81 SLX4	10 interacting genes: CHEK2 CSNK2A1 DDB1 EME1 EME2 RECQL5 SLX1A SLX4 SUMO2 UHRF1
Entrez ID		548593	80198
HPRD ID		18681	09419
Ensembl ID		ENSG00000132207	ENSG00000172732
Uniprot IDs		Q9BQ83	Q53ES5 Q96NY9
PDB IDs			2MC3 2ZIX 4P0P 4P0Q 4P0R 4P0S
Enriched GO Terms of Interacting Partners?
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