RNF34 and UBE2F

Data Source:
BioGRID (two hybrid)

		RNF34	UBE2F
Description		ring finger protein 34	ubiquitin conjugating enzyme E2 F (putative)
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Endomembrane System Nuclear Body Nuclear Speck	Nucleus Cytosol
	Molecular Function	P53 Binding Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Phosphatidylinositol Phosphate Binding	Protein Binding ATP Binding NEDD8 Transferase Activity NEDD8 Conjugating Enzyme Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Oxygen Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Protein Phosphopantetheinylation Post-translational Protein Modification Protein Neddylation
Pathways		Regulation of TP53 Degradation Antigen processing: Ubiquitination & Proteasome degradation	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Lean body mass ( 28552196)
Interacting Genes		10 interacting genes: APP APPBP2 DNAJA3 MAVS NOD1 PHF7 TRIM23 UBE2D2 UBE2F UBE2H	12 interacting genes: CUL1 CUL5 DCUN1D1 DCUN1D2 DCUN1D5 LCN2 NAE1 PAX6 RC3H1 RNF34 RNF7 UBA3
Entrez ID		80196	140739
HPRD ID		10509	14812
Ensembl ID		ENSG00000170633	ENSG00000184182
Uniprot IDs		A0A087WTM5 Q969K3	Q969M7
PDB IDs			2EDI 3FN1 4GBA
Enriched GO Terms of Interacting Partners?
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