SPSB1 and DDX4

Data Source:
BioGRID (unspecified method)

		SPSB1	DDX4
Description		splA/ryanodine receptor domain and SOCS box containing 1	DEAD-box helicase 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol SCF Ubiquitin Ligase Complex	Nucleus Cytoplasm P Granule Perinuclear Region Of Cytoplasm Pi-body PiP-body
	Molecular Function	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity	RNA Binding RNA Helicase Activity ATP Binding ATPase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification	Male Meiotic Nuclear Division Male Meiosis I Multicellular Organism Development Gamete Generation Spermatogenesis Negative Regulation Of Transposition Cell Differentiation Flagellated Sperm Motility Gene Silencing By RNA PiRNA Metabolic Process DNA Methylation Involved In Gamete Generation PiRNA Biosynthetic Process
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	PIWI-interacting RNA (piRNA) biogenesis
Drugs
Diseases
GWAS		Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Cognitive function ( 28093568) Dental caries ( 23064961) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Height ( 28552196 31562340) Immune response to anthrax vaccine ( 22658931) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Pulse pressure ( 27841878 30578418) Response to tocilizumab in rheumatoid arthritis ( 22491018) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 27841878 30578418)	Cocaine dependence ( 31212010)
Interacting Genes		14 interacting genes: ADPRH ATM DDX4 KDM1A MET NOS2 PAWR PRMT1 PRMT6 RASA1 SUV39H1 TRIM55 TRIM63 VWA5A	5 interacting genes: PIWIL2 RANBP9 SPSB1 SPSB2 SPSB4
Entrez ID		80176	54514
HPRD ID		18106	05593
Ensembl ID		ENSG00000171621	ENSG00000152670
Uniprot IDs		A0A024R4G8 Q96BD6	Q9NQI0
PDB IDs		2JK9 3F2O
Enriched GO Terms of Interacting Partners?
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