CCDC33 and MAPK9

Data Source:
BioGRID (two hybrid)

		CCDC33	MAPK9
Description		coiled-coil domain containing 33	mitogen-activated protein kinase 9
Image		No pdb structure
GO Annotations	Cellular Component	Peroxisome	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding	Protein Serine/threonine Kinase Activity JUN Kinase Activity MAP Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding
	Biological Process		Protein Phosphorylation JNK Cascade JUN Phosphorylation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Peptidyl-serine Phosphorylation Positive Regulation Of Protein Ubiquitination Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Regulation Of DNA-binding Transcription Factor Activity Protein Localization To Tricellular Tight Junction Cellular Response To Cadmium Ion Positive Regulation Of Podosome Assembly Positive Regulation Of Transcription Factor Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways			Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors
Drugs			Minocycline N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide Fostamatinib Halicin
Diseases
GWAS		Bacterial meningitis ( 31092817) Coffee consumption (cups per day) ( 31837886) Craniofacial microsomia ( 26853712) Diastolic blood pressure ( 30224653) Diisocyanate-induced asthma ( 25918132) Obesity-related traits ( 23251661) Systolic blood pressure ( 30578418)	Blood protein levels ( 30072576)
Interacting Genes		159 interacting genes: ABCF3 ABLIM3 ANKS1A AP1M1 APP ARHGEF6 ARIH2 ARMC7 ARNT2 BCCIP BLK BLZF1 BYSL C1orf109 CABP2 CALCOCO2 CCDC102B CCDC57 CCDC6 CCDC85B CCHCR1 CCNH CDC23 CDCA7L CDKN2B CENPP CFAP206 CHCHD3 CINP CIR1 CRYBA2 CRYBA4 CTNNA3 DGCR6 DIP2A DVL2 DVL3 EAF1 EFEMP2 EHMT2 EMC2 EMD ESRRG EXOC8 FAM124A FAM161A FAM214B FRS3 FXR2 GCC1 GPANK1 GPATCH2L GRN GYS1 HEXIM2 HGS HNRNPF HNRNPK HOOK2 HOXA1 HSF2BP IL16 ING5 ITGB1BP1 KANK2 KCTD19 KCTD9 KDM1A KHDRBS3 KIFC3 KLHL38 KXD1 L3MBTL2 LDOC1 LMO1 LMO2 LMO3 LNX1 MAGED1 MAGOHB MAPK9 MDFI MFAP1 MID2 MIPOL1 MISP MKRN3 MLH1 MOS NAB2 NCK2 NDOR1 NECAB2 NEFL NINL NME7 OSGIN1 OSTF1 PCSK5 PID1 PIK3R3 PIN1 PLA2G6 PLSCR1 PNMA1 PNMA2 POLR1C PPP2R3C PRKAA2 PRKAB2 PRPF31 PTGER3 PTK6 QARS1 RAD51D RAD54B RBMX RHOXF2 RNF6 SCNM1 SMAD3 SMARCB1 SMARCD1 SMYD1 SPAG5 SPG21 STK16 STX11 SYT17 TASOR2 TCEANC TGFB1 TMCC2 TNS2 TRAF2 TRIM23 TRIM37 TRIM42 TRIM59 TSC22D4 TSEN15 TSGA10 TTC19 TUFT1 TXK TXLNA UBASH3A UBQLN4 USHBP1 VPS52 WT1 YES1 ZBTB8A ZGPAT ZNF330 ZNF572 ZNF688 ZNF76 ZNRD2	112 interacting genes: ACP5 AKT1 ARRB1 ARRB2 ATF2 ATF7 BCL2L1 BCL2L11 BNIP5 C1orf105 C1orf94 CASP3 CBLL2 CCDC33 CDC16 CDC25B CDC25C CEP126 CEP44 CLU CTBP1 CTNNB1 CYHR1 DCX DTX3 DUSP10 DUSP16 DUSP19 DUSP4 EEF2K EFHC2 EGFR ELK1 ELK3 ENKD1 FBXO7 GFAP GOLGA6A GRB2 GSC2 H3-3A HDAC9 HSF1 IHO1 IRS1 ITGB3BP JDP2 JUN JUNB JUND KLHL8 KPNA3 L3MBTL3 LHX3 LMAN2 LNX1 LNX2 LZTS1 MACF1 MAP2K4 MAP2K7 MAP3K1 MAP3K10 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAPK5 MAPKBP1 MAPT MCRS1 MED12L MEOX1 MLIP NCF1 NCSTN NFATC3 NFATC4 NHSL2 PAX5 PBX4 PICK1 POU6F2 PPARG PRKD1 PSEN1 RASL10B RB1 RPS6KB1 RSPO4 SAXO1 SDCBP SF3B4 SH3BP5 SHMT1 SMAD2 SMAD3 SMCO3 SSU72 TCP10L TEX11 TOB1 TP53 TRAF2 TUSC2 WDR62 XPNPEP1 XPO7 ZBTB25 ZC2HC1C ZNF138 ZNF559 ZNHIT1
Entrez ID		80125	5601
HPRD ID		09959	04206
Ensembl ID		ENSG00000140481	ENSG00000050748
Uniprot IDs		Q8N5R6	D7R525 D7R526 P45984
PDB IDs			3E7O 3NPC 7CML
Enriched GO Terms of Interacting Partners?
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