KAT6A and UBE2U

Data Source:
BioGRID (two hybrid)

		KAT6A	UBE2U
Description		lysine acetyltransferase 6A	ubiquitin conjugating enzyme E2 U
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GO Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm Nucleolus Cytosol PML Body Nuclear Speck MOZ/MORF Histone Acetyltransferase Complex	HULC Complex
	Molecular Function	DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Acetyltransferase Activity Histone Binding	Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	DNA Packaging Nucleosome Assembly Protein Acetylation Histone Acetylation Myeloid Cell Differentiation Histone H3 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		HATs acetylate histones Regulation of TP53 Activity through Acetylation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Sleep duration ( 30531941)	Severe bacterial meningitis ( 31092817)
Interacting Genes		19 interacting genes: AKT1 ATN1 ATXN1 CREBBP H3-4 H3-5 H3C1 H3C14 H4-16 H4C1 H4C9 HEMGN MAFK PML RERE RUNX1 SPI1 TP53 UBE2U	68 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2
Entrez ID		7994	148581
HPRD ID		03244	14599
Ensembl ID		ENSG00000083168	ENSG00000177414
Uniprot IDs		A5PKX7 A5PLL3 Q92794	A0A140VJY9 Q5VVX9
PDB IDs		1M36 2LN0 2OZU 2RC4 3V43 4LJN 4LK9 4LKA 4LLB 5B75 5B76 5B77 5B78	1YRV
Enriched GO Terms of Interacting Partners?
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