RABEP2 and FRAT1

Data Source:
BioGRID (two hybrid)

		RABEP2	FRAT1
Description		rabaptin, RAB GTPase binding effector protein 2	FRAT regulator of WNT signaling pathway 1
Image		No pdb structure
GO Annotations	Cellular Component	Early Endosome Centrosome Cytosol Ciliary Basal Body Intracellular Membrane-bounded Organelle	Cytoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	GTPase Activator Activity Protein Binding Growth Factor Activity	Protein Binding
	Biological Process	Endocytosis Signal Transduction Protein Transport Cell Projection Organization Positive Regulation Of GTPase Activity Regulation Of Cilium Assembly	Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Destruction Complex Disassembly
Pathways			Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 31453325) Body mass index variance ( 31453325) Brain morphology (MOSTest) ( 32665545) Cannabis use ( 30150663) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Extremely high intelligence ( 29520040) HDL cholesterol levels ( 32203549) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Obesity ( 23563607)	Lymphocyte counts ( 32888494) Monocyte count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: FBXO25 FRAT1 MAP3K1 RAB4A RAB5A UBC VPS52	13 interacting genes: DVL1 GPRASP2 GRN GSK3B KCNK5 KRT18 LAMC3 LMAN2 LTBP4 PLSCR1 PSMA3 RABEP2 TDRD7
Entrez ID		79874	10023
HPRD ID		17948	03935
Ensembl ID		ENSG00000177548	ENSG00000165879
Uniprot IDs		Q9H5N1	Q92837
PDB IDs			1GNG 3ZRK 3ZRL 3ZRM 4AFJ 5OY4
Enriched GO Terms of Interacting Partners?
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