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FRAT1 and PLSCR1
Data Source:
BioGRID
(two hybrid)
FRAT1
PLSCR1
Description
FRAT regulator of WNT signaling pathway 1
phospholipid scramblase 1
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Intracellular Membrane-bounded Organelle
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Membrane
Membrane Raft
Perinuclear Region Of Cytoplasm
Collagen-containing Extracellular Matrix
Extracellular Exosome
Molecular Function
Protein Binding
Magnesium Ion Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Virus Receptor Activity
DNA Binding
Nuclease Activity
Epidermal Growth Factor Receptor Binding
Calcium Ion Binding
Protein Binding
Zinc Ion Binding
SH3 Domain Binding
Phospholipid Scramblase Activity
Enzyme Binding
Lead Ion Binding
CD4 Receptor Binding
Mercury Ion Binding
Biological Process
Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Beta-catenin Destruction Complex Disassembly
Phosphatidylserine Biosynthetic Process
Apoptotic Process
Acute-phase Response
Response To Lead Ion
Positive Regulation Of Gene Expression
Plasma Membrane Phospholipid Scrambling
Platelet Activation
Regulation Of Mast Cell Activation
Response To Interferon-beta
Negative Regulation Of Viral Genome Replication
Positive Regulation Of Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Viral Entry Into Host Cell
Negative Regulation Of Phagocytosis
Defense Response To Virus
Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Phosphatidylserine Exposure On Apoptotic Cell Surface
Nucleic Acid Phosphodiester Bond Hydrolysis
Positive Regulation Of Chromosome Separation
Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Pathways
Beta-catenin phosphorylation cascade
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases
GWAS
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
White blood cell count (
32888494
)
Gut microbiota (beta diversity) (
27723756
)
Interacting Genes
13 interacting genes:
DVL1
GPRASP2
GRN
GSK3B
KCNK5
KRT18
LAMC3
LMAN2
LTBP4
PLSCR1
PSMA3
RABEP2
TDRD7
129 interacting genes:
ABL1
ADAMTSL4
ADCY7
ANXA11
APP
ARNT2
ATG12
ATN1
BACE1
BCL6B
C10orf62
CATSPER1
CCDC33
CCER1
CDC42EP1
CHRD
CNTFR
CPSF6
CRK
CRKL
CRY1
CTBP1-DT
CTSZ
DAZAP2
DDIAS
DEF6
DEPP1
DHRS1
DLK2
DMRT3
DOCK2
DTX2
EFEMP2
EGFR
ENKD1
EP300
ESR2
EWSR1
EXD3
FAM107A
FBLN1
FBXL18
FRAT1
FRS3
GDPD5
GLRX3
GNAI2
GPRIN2
HEY2
HOXA1
HOXA9
HOXB6
HRG
ILF3
INTS11
IP6K2
IQCN
KIF1A
KRTAP10-11
KRTAP10-3
KRTAP10-9
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP5-6
KRTAP9-2
LASP1
LCE2D
LCE3C
LCE4A
LGALS9C
LINC00663
LINC01547
LONRF1
MAPK6
MED15
MGAT5B
MVP
NECAP2
NEU4
NOC4L
NPDC1
NR0B2
NTN4
OGDH
P2RY6
PCED1A
PGLS
PHLDA1
PITX1
PKD2
PLSCR3
PLSCR4
PML
PRKCD
PRR13
RAMAC
RASD1
RBL1
RERE
RGS3
RXRB
SCNM1
SF1
SHC1
SLC25A6
SLC35A2
SLPI
SMARCC1
SMCP
SPATA8
SPG7
SPRY2
SRC
STK16
TFG
TRAF4
TRIM42
VASP
VPS37C
VSIR
YIPF3
ZBTB16
ZNF417
ZNF581
ZNF587
ZNF638
ZNF688
ZNF764
Entrez ID
10023
5359
HPRD ID
03935
08855
Ensembl ID
ENSG00000165879
ENSG00000188313
Uniprot IDs
Q92837
O15162
PDB IDs
1GNG
3ZRK
3ZRL
3ZRM
4AFJ
5OY4
1Y2A
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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