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FRAT1 and GRN
Data Source:
BioGRID
(two hybrid)
FRAT1
GRN
Description
FRAT regulator of WNT signaling pathway 1
granulin precursor
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Intracellular Membrane-bounded Organelle
Extracellular Region
Extracellular Space
Lysosome
Lysosomal Membrane
Endosome
Late Endosome
Endoplasmic Reticulum
Golgi Apparatus
Trans-Golgi Network
Plasma Membrane
Membrane
Azurophil Granule Lumen
Extracellular Exosome
Molecular Function
Protein Binding
RNA Binding
Cytokine Activity
Protein Binding
Growth Factor Activity
Chaperone Binding
Biological Process
Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Beta-catenin Destruction Complex Disassembly
Astrocyte Activation Involved In Immune Response
Microglial Cell Activation Involved In Immune Response
Lysosome Organization
Lysosomal Transport
Lysosomal Lumen Acidification
Signal Transduction
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Cell Migration
Neutrophil Degranulation
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Axon Regeneration
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Inflammatory Response
Protein Stabilization
Negative Regulation Of Respiratory Burst Involved In Inflammatory Response
Positive Regulation Of Inflammatory Response To Wounding
Positive Regulation Of Defense Response To Bacterium
Negative Regulation Of Neutrophil Activation
Positive Regulation Of Protein Folding
Negative Regulation Of Microglial Cell Activation
Positive Regulation Of Aspartic-type Peptidase Activity
Positive Regulation Of Lysosome Organization
Pathways
Beta-catenin phosphorylation cascade
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Neutrophil degranulation
Drugs
Diseases
Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
White blood cell count (
32888494
)
Blood protein levels (
30072576
29875488
)
Brain morphology (MOSTest) (
32665545
)
Intracranial volume (
22504418
)
Progranulin levels (
29186428
)
Subcortical brain region volumes (
25607358
)
Interacting Genes
13 interacting genes:
DVL1
GPRASP2
GRN
GSK3B
KCNK5
KRT18
LAMC3
LMAN2
LTBP4
PLSCR1
PSMA3
RABEP2
TDRD7
79 interacting genes:
ARFGAP1
ATN1
ATXN7
C22orf39
C4orf17
CACNA1A
CCDC33
CCNG1
CCNT1
CDK9
CLPP
CRCT1
CRKL
CRY1
CXCL5
CYSRT1
DLK1
DLX2
DMRT3
ECM1
ELANE
FAM131C
FAM76B
FANCL
FRAT1
GFI1B
GLRX3
GNE
HK3
HOXA1
HSPG2
KRT18
KRT34
KRTAP1-1
KRTAP1-5
KRTAP10-7
KRTAP10-8
KRTAP11-1
KRTAP12-1
KRTAP13-2
KRTAP15-1
KRTAP26-1
KRTAP5-9
KRTAP6-1
KRTAP6-2
LCE1A
LCE1D
LCE1E
LCE2B
LCE2D
LCE3C
LCE3E
LCE4A
MEOX2
NLK
NUFIP2
OTX1
P4HB
PIK3R2
PLLP
POT1
POU4F2
PRKAB2
PTPMT1
RAC1
SGTA
SLC13A1
SLPI
SMAD9
SMCP
SPRY2
TAT
TGM2
TLE5
TOP3B
TSPAN4
UTP23
VASN
YY1
Entrez ID
10023
2896
HPRD ID
03935
00733
Ensembl ID
ENSG00000165879
ENSG00000030582
Uniprot IDs
Q92837
P28799
PDB IDs
1GNG
3ZRK
3ZRL
3ZRM
4AFJ
5OY4
1G26
2JYE
2JYT
2JYU
2JYV
6NUG
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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