RNF122 and UBE2L6

Data Source:
BioGRID (two hybrid)

		RNF122	UBE2L6
Description		ring finger protein 122	ubiquitin conjugating enzyme E2 L6
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Golgi Apparatus Endomembrane System Integral Component Of Membrane	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding ISG15 Transferase Activity Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Negative Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination	Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Phosphopantetheinylation Translesion Synthesis ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Cellular Protein Metabolic Process
Pathways			ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Pulse pressure ( 30578418)	Blood protein levels ( 28240269)
Interacting Genes		12 interacting genes: AQP1 CDS2 CTSA DDX58 GPR37L1 PLLP UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L6 UBE2N	40 interacting genes: ARHGDIA ARIH1 ARIH2 CBLC DTX3 FLT3 HERC5 LONRF1 MAP3K1 MID1 MUL1 NEDD4L PJA2 PRKN RBCK1 RBX1 RNF122 RNF125 RNF144A RNF144B RNF150 RNF19A RNF216 RNF25 RNF4 RNF40 RUNX1 SIAH1 SIAH2 SPEN TOPORS TRAF7 TRIM25 TRIM27 TRIM62 TRIM8 UBA1 UBA6 UBA7 UBE3A
Entrez ID		79845	9246
HPRD ID		11498	04867
Ensembl ID		ENSG00000133874	ENSG00000156587
Uniprot IDs		Q9H9V4	O14933
PDB IDs			1WZV 1WZW 2KJH
Enriched GO Terms of Interacting Partners?
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