RNF122 and CTSA

Data Source:
BioGRID (two hybrid)

		RNF122	CTSA
Description		ring finger protein 122	cathepsin A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Golgi Apparatus Endomembrane System Integral Component Of Membrane	Extracellular Region Lysosome Endoplasmic Reticulum Membrane Azurophil Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Lumenal Side Of Lysosomal Membrane
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Carboxypeptidase Activity Serine-type Carboxypeptidase Activity Enzyme Activator Activity
	Biological Process	Negative Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination	Proteolysis Glycosphingolipid Metabolic Process Intracellular Protein Transport Regulation Of Protein Stability Neutrophil Degranulation Regulation Of Catalytic Activity Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Chaperone-mediated Autophagy
Pathways			Glycosphingolipid metabolism MHC class II antigen presentation Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation
Drugs
Diseases			Galactosialidosis
GWAS		Pulse pressure ( 30578418)
Interacting Genes		12 interacting genes: AQP1 CDS2 CTSA DDX58 GPR37L1 PLLP UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L6 UBE2N	45 interacting genes: AHNAK2 AQP2 AQP6 ARL13B ASPH BSND CD79A COQ9 CPLX4 CREB3L1 CSPG5 ERGIC3 FAM209A FKBP7 FNDC9 GLB1 GORAB HIBADH LAMP2 LMNA LTB4R2 MFSD14B MGST3 MUC1 MYG1 NEU1 PSCA REEP4 RHBDD1 RNF122 SAR1A SGMS2 SIGLEC12 SLC18A1 SLC30A2 SPN SSMEM1 STX2 THAP4 TMEM139 TMEM154 TMEM237 TMEM31 TMEM35A TMX2
Entrez ID		79845	5476
HPRD ID		11498	02020
Ensembl ID		ENSG00000133874	ENSG00000064601
Uniprot IDs		Q9H9V4	B4E324 P10619 X6R5C5 X6R8A1
PDB IDs			1IVY 3BP4 3BP7 3BXN 4AZ0 4AZ3 4CI9 4CIA 4CIB 4MWS 4MWT 6WIA
Enriched GO Terms of Interacting Partners?
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