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C3orf52 and CCL21
Data Source:
BioGRID
(two hybrid)
C3orf52
CCL21
Description
chromosome 3 open reading frame 52
C-C motif chemokine ligand 21
Image
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum Membrane
Integral Component Of Membrane
Extracellular Region
Extracellular Space
Molecular Function
Protein Binding
Protein Binding
Chemokine Activity
CCR7 Chemokine Receptor Binding
Chemokine Receptor Binding
CCR Chemokine Receptor Binding
Biological Process
Establishment Of T Cell Polarity
Immunological Synapse Formation
Positive Regulation Of Cell-matrix Adhesion
Dendritic Cell Chemotaxis
Monocyte Chemotaxis
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Inflammatory Response
Immune Response
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Positive Regulation Of Glycoprotein Biosynthetic Process
Positive Regulation Of T Cell Chemotaxis
Neutrophil Chemotaxis
Positive Regulation Of Actin Filament Polymerization
Positive Regulation Of Pseudopodium Assembly
T Cell Costimulation
Ruffle Organization
Positive Regulation Of Cell Adhesion Mediated By Integrin
Response To Prostaglandin E
Mesangial Cell-matrix Adhesion
Chemokine (C-C Motif) Ligand 21 Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of GTPase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Eosinophil Chemotaxis
Lymphocyte Chemotaxis
Positive Regulation Of Receptor-mediated Endocytosis
Cell Maturation
Positive Regulation Of Chemotaxis
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Filopodium Assembly
Positive Regulation Of Protein Kinase B Signaling
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Neutrophil Chemotaxis
Activation Of GTPase Activity
Dendritic Cell Dendrite Assembly
Negative Regulation Of Leukocyte Tethering Or Rolling
Cellular Response To Chemokine
Positive Regulation Of Cell Motility
Positive Regulation Of T Cell Migration
Positive Regulation Of Myeloid Dendritic Cell Chemotaxis
Negative Regulation Of Dendritic Cell Dendrite Assembly
Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways
Chemokine receptors bind chemokines
G alpha (i) signalling events
Drugs
Diseases
GWAS
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Autoimmune traits (pleiotropy) (
30572963
)
Blood protein levels (
30072576
)
Celiac disease (
30572963
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Rheumatoid arthritis (
30423114
18794853
30572963
23143596
24390342
20453842
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Interacting Genes
72 interacting genes:
ADGRG3
AGER
AHNAK2
AMIGO1
AQP6
ATP1B4
BIK
CCL21
CCL26
CD33
CHST13
CLDN7
CLEC10A
CNMD
CPLX4
CREB3
DEXI
ERGIC3
ERP29
ESAM
FAM209A
FFAR2
FNDC9
FOLH1
FUT3
GJA8
GJB1
GOLM2
GORAB
HHLA2
HSD17B13
KEL
KIR2DL3
KLRC1
LEUTX
LHFPL5
LMNA
LRRC25
MFF
MGST2
MGST3
MRGPRX3
MUC1
NCR3LG1
NEMP1
NPDC1
NSG2
PVR
QPCTL
REEP3
RNF150
SAR1A
SGTA
SIGLECL1
SLC10A2
SLC16A2
SLC23A2
SLC39A2
SPRING1
ST6GALNAC3
STOM
SYNE4
TIMMDC1
TMEM179B
TMEM237
TMEM45B
TMEM52B
TMEM80
TMPRSS2
TMX2
UPK2
ZNRF3
32 interacting genes:
ACKR2
ACKR4
C3orf52
CCL13
CCL17
CCL23
CCL24
CCL26
CCL28
CCL5
CCR7
CTSD
CXCL10
CXCL11
CXCL12
CXCL13
CXCL14
CXCL17
CXCL2
CXCL9
GOT2
IGFBP7
LRRK1
OTP
PF4
PF4V1
PPBP
TMEM107
UBQLN4
VCAN
XCL1
XCL2
Entrez ID
79669
6366
HPRD ID
08018
04113
Ensembl ID
ENSG00000114529
ENSG00000137077
Uniprot IDs
Q5BVD1
O00585
PDB IDs
2L4N
5EKI
Enriched GO Terms of Interacting Partners
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