DHX58 and DICER1

Data Source:
BioGRID (pull down)

		DHX58	DICER1
Description		DExH-box helicase 58	dicer 1, ribonuclease III
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GO Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol RISC Complex Dendrite Growth Cone ARC Complex Perinuclear Region Of Cytoplasm Extracellular Exosome RISC-loading Complex
	Molecular Function	DNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding ATP Binding Zinc Ion Binding	DNA Binding RNA Binding Double-stranded RNA Binding Helicase Activity Endoribonuclease Activity Ribonuclease III Activity Deoxyribonuclease I Activity Protein Binding ATP Binding Protein Domain Specific Binding SiRNA Binding Metal Ion Binding Pre-miRNA Binding
	Biological Process	Response To Virus Response To Bacterium Viral Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Defense Response To Virus Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic DNA Fragmentation MiRNA Metabolic Process Negative Regulation Of Schwann Cell Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Schwann Cell Differentiation Nerve Development Production Of SiRNA Involved In RNA Interference Targeting Of MRNA For Destruction Involved In RNA Interference Pre-miRNA Processing Positive Regulation Of Myelination Peripheral Nervous System Myelin Formation Negative Regulation Of Tumor Necrosis Factor Production Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference SiRNA Loading Onto RISC Involved In RNA Interference Tube Formation Production Of MiRNAs Involved In Gene Silencing By MiRNA MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Conversion Of Ds SiRNA To Ss SiRNA NIK/NF-kappaB Signaling Neuron Projection Morphogenesis RNA Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta	MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Fasting plasma glucose ( 31932636) Mean spheric corpuscular volume ( 32888494)	Body mass index ( 25760438) Body mass index (dietary energy interaction) ( 23192594) Chin dimples ( 27182965) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Heel bone mineral density ( 30598549 28869591) Metabolite levels ( 23823483) Nose size ( 27182965) Plasma anti-thyroid peroxidase levels ( 29678681) Response to statin therapy ( 20339536)
Interacting Genes		9 interacting genes: AGO2 AP2B1 APP DHX30 DICER1 EIF2AK2 EIF6 NKRF STAU2	11 interacting genes: AGO1 AGO2 ALOX5 DHX58 EIF2AK2 PIWIL1 PIWIL2 PIWIL4 PRKAB2 PRKRA TARBP2
Entrez ID		79132	23405
HPRD ID		13115	05875
Ensembl ID		ENSG00000108771	ENSG00000100697
Uniprot IDs		A0A024R1Y5 Q96C10	Q9UPY3
PDB IDs		2RQA 2W4R 3EQT	2EB1 4NGB 4NGC 4NGD 4NGF 4NGG 4NH3 4NH5 4NH6 4NHA 4WYQ 5ZAK 5ZAL 5ZAM
Enriched GO Terms of Interacting Partners?
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