DICER1 and PIWIL2

Data Source:
HPRD (in vivo, in vitro)

		DICER1	PIWIL2
Description		dicer 1, ribonuclease III	piwi like RNA-mediated gene silencing 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol RISC Complex Dendrite Growth Cone ARC Complex Perinuclear Region Of Cytoplasm Extracellular Exosome RISC-loading Complex	Nucleus Cytoplasm Perinucleolar Chromocenter Chromatoid Body P Granule Pi-body Dense Body PET Complex
	Molecular Function	DNA Binding RNA Binding Double-stranded RNA Binding Helicase Activity Endoribonuclease Activity Ribonuclease III Activity Deoxyribonuclease I Activity Protein Binding ATP Binding Protein Domain Specific Binding SiRNA Binding Metal Ion Binding Pre-miRNA Binding	MRNA Binding Endoribonuclease Activity Protein Binding PiRNA Binding Metal Ion Binding Polysome Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic DNA Fragmentation MiRNA Metabolic Process Negative Regulation Of Schwann Cell Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Schwann Cell Differentiation Nerve Development Production Of SiRNA Involved In RNA Interference Targeting Of MRNA For Destruction Involved In RNA Interference Pre-miRNA Processing Positive Regulation Of Myelination Peripheral Nervous System Myelin Formation Negative Regulation Of Tumor Necrosis Factor Production Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference SiRNA Loading Onto RISC Involved In RNA Interference Tube Formation Production Of MiRNAs Involved In Gene Silencing By MiRNA MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Conversion Of Ds SiRNA To Ss SiRNA NIK/NF-kappaB Signaling Neuron Projection Morphogenesis RNA Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	RNA 5'-end Processing Multicellular Organism Development Spermatogenesis Negative Regulation Of Transposition Germ-line Stem Cell Population Maintenance Gene Silencing By RNA PiRNA Metabolic Process Negative Regulation Of Circadian Rhythm DNA Methylation Involved In Gamete Generation Positive Regulation Of Translation Oogenesis Rhythmic Process Meiotic Cell Cycle Positive Regulation Of Meiosis I Positive Regulation Of Histone H3-K14 Acetylation RNA Phosphodiester Bond Hydrolysis, Endonucleolytic PiRNA Biosynthetic Process Positive Regulation Of Histone H3-K9 Acetylation
Pathways		MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis	PIWI-interacting RNA (piRNA) biogenesis
Drugs
Diseases
GWAS		Body mass index ( 25760438) Body mass index (dietary energy interaction) ( 23192594) Chin dimples ( 27182965) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Heel bone mineral density ( 30598549 28869591) Metabolite levels ( 23823483) Nose size ( 27182965) Plasma anti-thyroid peroxidase levels ( 29678681) Response to statin therapy ( 20339536)	Hypertriglyceridemia ( 23505323)
Interacting Genes		11 interacting genes: AGO1 AGO2 ALOX5 DHX58 EIF2AK2 PIWIL1 PIWIL2 PIWIL4 PRKAB2 PRKRA TARBP2	3 interacting genes: DDX4 DICER1 TBCB
Entrez ID		23405	55124
HPRD ID		05875	11434
Ensembl ID		ENSG00000100697	ENSG00000197181
Uniprot IDs		Q9UPY3	Q8TC59 W0HK13
PDB IDs		2EB1 4NGB 4NGC 4NGD 4NGF 4NGG 4NH3 4NH5 4NH6 4NHA 4WYQ 5ZAK 5ZAL 5ZAM	3O7X 3QIR
Enriched GO Terms of Interacting Partners?
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