DICER1 and PIWIL1

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		DICER1	PIWIL1
Description		dicer 1, ribonuclease III	piwi like RNA-mediated gene silencing 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol RISC Complex Dendrite Growth Cone ARC Complex Perinuclear Region Of Cytoplasm Extracellular Exosome RISC-loading Complex	Nucleus Cytoplasm Chromatoid Body P Granule Dense Body
	Molecular Function	DNA Binding RNA Binding Double-stranded RNA Binding Helicase Activity Endoribonuclease Activity Ribonuclease III Activity Deoxyribonuclease I Activity Protein Binding ATP Binding Protein Domain Specific Binding SiRNA Binding Metal Ion Binding Pre-miRNA Binding	Single-stranded RNA Binding MRNA Binding Endoribonuclease Activity Protein Binding Protein Kinase Binding PiRNA Binding Metal Ion Binding MRNA Cap Binding Complex Binding Polysome Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic DNA Fragmentation MiRNA Metabolic Process Negative Regulation Of Schwann Cell Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Schwann Cell Differentiation Nerve Development Production Of SiRNA Involved In RNA Interference Targeting Of MRNA For Destruction Involved In RNA Interference Pre-miRNA Processing Positive Regulation Of Myelination Peripheral Nervous System Myelin Formation Negative Regulation Of Tumor Necrosis Factor Production Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference SiRNA Loading Onto RISC Involved In RNA Interference Tube Formation Production Of MiRNAs Involved In Gene Silencing By MiRNA MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Conversion Of Ds SiRNA To Ss SiRNA NIK/NF-kappaB Signaling Neuron Projection Morphogenesis RNA Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Regulation Of Translation Multicellular Organism Development Spermatogenesis Spermatid Development Negative Regulation Of Transposition Gene Silencing By RNA PiRNA Metabolic Process Spermatogenesis, Exchange Of Chromosomal Proteins Meiotic Cell Cycle RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis	PIWI-interacting RNA (piRNA) biogenesis
Drugs
Diseases
GWAS		Body mass index ( 25760438) Body mass index (dietary energy interaction) ( 23192594) Chin dimples ( 27182965) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Heel bone mineral density ( 30598549 28869591) Metabolite levels ( 23823483) Nose size ( 27182965) Plasma anti-thyroid peroxidase levels ( 29678681) Response to statin therapy ( 20339536)	Menopause (age at onset) ( 26414677)
Interacting Genes		11 interacting genes: AGO1 AGO2 ALOX5 DHX58 EIF2AK2 PIWIL1 PIWIL2 PIWIL4 PRKAB2 PRKRA TARBP2	2 interacting genes: DICER1 TRIM54
Entrez ID		23405	9271
HPRD ID		05875	10409
Ensembl ID		ENSG00000100697	ENSG00000125207
Uniprot IDs		Q9UPY3	A0A024RBS5 Q96J94
PDB IDs		2EB1 4NGB 4NGC 4NGD 4NGF 4NGG 4NH3 4NH5 4NH6 4NHA 4WYQ 5ZAK 5ZAL 5ZAM	2L5C 2L5D 3O3I 3O6E 3O7V 6PI7
Enriched GO Terms of Interacting Partners?
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