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CREB3 and HMOX1
Data Source:
BioGRID
(two hybrid)
CREB3
HMOX1
Description
cAMP responsive element binding protein 3
heme oxygenase 1
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Membrane
Chromatin
Nucleus
Nucleoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Integral Component Of Membrane
Extracellular Space
Nucleus
Nucleolus
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Caveola
Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
CAMP Response Element Binding
Sequence-specific Double-stranded DNA Binding
Heme Oxygenase (decyclizing) Activity
Phospholipase D Activity
Structural Molecule Activity
Protein Binding
Enzyme Binding
Heme Binding
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Biological Process
Regulation Of Transcription By RNA Polymerase II
Chemotaxis
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response
Viral Process
Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Monocyte Chemotaxis
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Angiogenesis
Endothelial Cell Proliferation
Wound Healing Involved In Inflammatory Response
Negative Regulation Of Leukocyte Migration
Heme Oxidation
Cellular Iron Ion Homeostasis
Response To Oxidative Stress
Small GTPase Mediated Signal Transduction
Excretion
Regulation Of Blood Pressure
Cell Death
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Negative Regulation Of Muscle Cell Apoptotic Process
Smooth Muscle Hyperplasia
Positive Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Cytokine-mediated Signaling Pathway
Cellular Response To Nutrient
Positive Regulation Of Chemokine Production
Negative Regulation Of Mast Cell Cytokine Production
Erythrocyte Homeostasis
Low-density Lipoprotein Particle Clearance
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron
Cellular Response To Heat
Response To Nicotine
Intracellular Signal Transduction
Heme Catabolic Process
Response To Drug
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Mast Cell Degranulation
Negative Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Response To Estrogen
Regulation Of Angiogenesis
Positive Regulation Of Angiogenesis
Positive Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Smooth Muscle Cell Proliferation
Regulation Of DNA-binding Transcription Factor Activity
Iron Ion Homeostasis
Cellular Response To Arsenic-containing Substance
Cellular Response To Cadmium Ion
Cellular Response To Hypoxia
Cellular Response To Cisplatin
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Liver Regeneration
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Negative Regulation Of Epithelial Cell Apoptotic Process
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways
CREB3 factors activate genes
CREB3 factors activate genes
Heme degradation
Interleukin-4 and Interleukin-13 signaling
Iron uptake and transport
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
NADH
Formic acid
Biliverdine IX Alpha
12-Phenylheme
2-Phenylheme
Verdoheme
Stannsoporfin
1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE
1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone
Diseases
GWAS
Brain morphology (MOSTest) (
32665545
)
Hippocampal volume in mild cognitive impairment (
29274321
)
Obesity-related traits (
23251661
)
Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease (
29748315
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
205 interacting genes:
ABHD16A
ACKR2
ACSF2
ACSL5
ADTRP
AGER
AGPAT3
ALG3
ALG8
APH1A
APOA2
APOD
APPBP2
AQP1
AQP2
AQP4
AQP5
ATF3
ATF4
ATP6AP2
ATP6V0C
BCAP29
BCAT2
BCL2L1
BIK
BNIP2
BNIP3
BTN2A2
C2
C3orf52
CACFD1
CCR1
CD207
CD82
CDS2
CEBPG
CELA3A
CES1
CFHR5
CGRRF1
CHMP7
CLCN7
CLDN19
CLDND2
CLP1
CMTM5
CNPY3
CREB3L1
CREB3L3
CT45A5
CTSW
CYB561
CYB5B
CYBC1
CYBRD1
CYP4F2
DDIT3
DNAJC30
DOLK
DRAM1
EBP
EMC6
EMD
ERG28
FA2H
FAM3A
FAM3C
FDFT1
FDPS
FIS1
FMO1
FMO3
FXYD3
FXYD6
GJA1
GJB2
GYPA
HCFC1
HDAC3
HMOX1
HVCN1
ICAM4
IGFBP5
ITM2B
JUN
KCNK1
KLHL30-AS1
KRTCAP2
LAT
LHFPL5
LILRB5
LMBR1L
LMNA
LPCAT2
LTA
MAL2
MALL
MARCHF5
MFSD11
MFSD5
MGST2
MRPL57
MS4A1
MYADM
NAA10
NDUFB6
NEU1
NFE2L2
NFE2L3
NFIL3
NKG7
NRG4
ORMDL1
OS9
P4HA2
PLLP
PLN
PLP1
PLPP1
PLTP
PMP22
PNLIPRP1
PSENEN
PTCH1
PTDSS1
PTPN9
RAB23
RABAC1
RHEB
RIMS3
RPRM
RPS3A
RRAS2
RUSF1
SACM1L
SAR1B
SCAMP4
SCAMP5
SCLY
SCP2
SEC22B
SEC61G
SELENOK
SERINC1
SFT2D2
SFTPC
SFXN3
SHMT2
SLC19A3
SLC29A1
SLC29A2
SLC29A3
SLC2A3
SLC2A4
SLC30A2
SLC35C2
SLC38A1
SLC39A13
SLC41A2
SLC41A3
SLC49A3
SLC50A1
SLC7A9
SPOCK3
SQLE
ST6GAL2
STARD3
STX7
STX8
SYNGR1
SYNPR
TAP1
TECR
TIMM17B
TIMM23B
TM4SF4
TMEM100
TMEM115
TMEM140
TMEM14A
TMEM14B
TMEM14C
TMEM19
TMEM203
TMEM222
TMEM230
TMEM234
TMEM243
TMEM51
TMEM54
TRAM1
TRAM1L1
TSPAN2
TSPAN4
TSPAN7
TTLL5
UBE2J1
UNC50
USE1
VKORC1
VTI1B
YIPF2
ZDHHC11
ZDHHC21
ZDHHC9
40 interacting genes:
AKT1
AQP6
ARL13B
ASL
BLVRB
CD79A
COQ9
CPLX4
CPSF1
CRB3
CREB3
CYB561
CYBRD1
ELOVL4
ELOVL5
ELOVL6
ERGIC3
FAM174A
FAM209A
FAM210B
GPR152
JAGN1
KASH5
LMNA
MSMO1
NOS1
PDZK1IP1
POR
POT1
PTGER4
SEC11C
SLC16A7
SMO
STX1A
TERF1
TLCD4
TM4SF19
TMEM14B
TMIE
TUT1
Entrez ID
10488
3162
HPRD ID
07339
00782
Ensembl ID
ENSG00000107175
ENSG00000100292
Uniprot IDs
O43889
P09601
Q6FH11
PDB IDs
1N3U
1N45
1NI6
1OYK
1OYL
1OZE
1OZL
1OZR
1OZW
1S13
1S8C
1T5P
1TWN
1TWR
1XJZ
1XK0
1XK1
1XK2
1XK3
3CZY
3HOK
3K4F
3TGM
4WD4
5BTQ
6EHA
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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