MAPKAPK3 and RAB2A

Data Source:
BioGRID (two hybrid)

		MAPKAPK3	RAB2A
Description		MAPK activated protein kinase 3	RAB2A, member RAS oncogene family
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Golgi Membrane Nucleus Lysosomal Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Toll-like Receptor Signaling Pathway Signal Transduction Peptidyl-serine Phosphorylation Response To Lipopolysaccharide Response To Cytokine Intracellular Signal Transduction Macropinocytosis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Protein Transport Post-translational Protein Modification
Pathways		p38MAPK events Oxidative Stress Induced Senescence VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation	Golgi Cisternae Pericentriolar Stack Reorganization RAB geranylgeranylation
Drugs		2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Diseases
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) High light scatter reticulocyte count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Autoimmune thyroid disease ( 32581359) Estimated glomerular filtration rate ( 31152163) Low density lipoprotein cholesterol levels ( 32154731) Neutrophil count ( 32888494) Systemic sclerosis ( 31672989) Total cholesterol levels ( 29083408)
Interacting Genes		21 interacting genes: APP ATF1 BECN1 COPS6 EEF2 EEF2K EZH2 HSPB1 IGHM LINC02582 MAPK13 MAPK14 NEDD4 NEDD4L RAB2A RCSD1 SMS SRPK2 SUMO3 TCF3 THAP12	27 interacting genes: BLZF1 CBFB CCDC125 CFL2 FAM114A1 FAM114A2 FAM71A FAM71C FAM71F2 FRMD1 GAPDH GDI2 GOLGA2 GORASP2 HES6 ICA1 MAPK6 MAPKAPK3 PMAIP1 PRKCI RBSN RGS2 SGSM2 STAMBPL1 TBC1D25 TMEM70 TRIM7
Entrez ID		7867	5862
HPRD ID		03678	01539
Ensembl ID		ENSG00000114738	ENSG00000104388
Uniprot IDs		A0A024R2W7 Q16644	A0A024R7V6 P61019
PDB IDs		3FHR 3FXW 3R1N 3SHE	1Z0A
Enriched GO Terms of Interacting Partners?
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