RAB2A and PMAIP1

Data Source:
BioGRID (two hybrid)

		RAB2A	PMAIP1
Description		RAB2A, member RAS oncogene family	phorbol-12-myristate-13-acetate-induced protein 1
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Lysosomal Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome Extracellular Exosome	Nucleus Mitochondrion Mitochondrial Outer Membrane Cytosol
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Protein Transport Post-translational Protein Modification	Release Of Cytochrome C From Mitochondria Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Proteasomal Protein Catabolic Process Positive Regulation Of Glucose Metabolic Process Negative Regulation Of Mitochondrial Membrane Potential Cellular Response To Glucose Starvation Regulation Of Apoptotic Process T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To DsRNA Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Mitochondrial Membrane Permeability Defense Response To Virus Cellular Response To Hypoxia Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Reactive Oxygen Species Metabolic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Golgi Cisternae Pericentriolar Stack Reorganization RAB geranylgeranylation	Activation of NOXA and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Estimated glomerular filtration rate ( 31152163) Low density lipoprotein cholesterol levels ( 32154731) Neutrophil count ( 32888494) Systemic sclerosis ( 31672989) Total cholesterol levels ( 29083408)	Apolipoprotein A1 levels ( 32203549) Body mass index ( 26426971 23669352 28892062) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Chronic lymphocytic leukemia ( 26956414 23770605) Coronary artery disease ( 26343387 33020668) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 31562340) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Regular attendance at a pub or social club ( 29970889) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		27 interacting genes: BLZF1 CBFB CCDC125 CFL2 FAM114A1 FAM114A2 FAM71A FAM71C FAM71F2 FRMD1 GAPDH GDI2 GOLGA2 GORASP2 HES6 ICA1 MAPK6 MAPKAPK3 PMAIP1 PRKCI RBSN RGS2 SGSM2 STAMBPL1 TBC1D25 TMEM70 TRIM7	10 interacting genes: BAX BCL2 BCL2A1 BCL2L1 GSK3B MCL1 PPBP RAB2A RNF7 ZBTB16
Entrez ID		5862	5366
HPRD ID		01539	12002
Ensembl ID		ENSG00000104388	ENSG00000141682
Uniprot IDs		A0A024R7V6 P61019	A0A0S2Z490 Q13794
PDB IDs		1Z0A	3MQP
Enriched GO Terms of Interacting Partners?
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