MAPKAPK3 and TCF3

Data Source:
HPRD (in vivo, two hybrid)

		MAPKAPK3	TCF3
Description		MAPK activated protein kinase 3	transcription factor 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Heterodimerization Activity Repressing Transcription Factor Binding Vitamin D Response Element Binding E-box Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Toll-like Receptor Signaling Pathway Signal Transduction Peptidyl-serine Phosphorylation Response To Lipopolysaccharide Response To Cytokine Intracellular Signal Transduction Macropinocytosis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II B Cell Lineage Commitment Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Nervous System Development B Cell Differentiation Immunoglobulin V(D)J Recombination Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		p38MAPK events Oxidative Stress Induced Senescence VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation	Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs		2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Diseases			Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) High light scatter reticulocyte count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Hodgkin's lymphoma ( 29196614 24920014) Objective response to lithium treatment ( 26503763)
Interacting Genes		21 interacting genes: APP ATF1 BECN1 COPS6 EEF2 EEF2K EZH2 HSPB1 IGHM LINC02582 MAPK13 MAPK14 NEDD4 NEDD4L RAB2A RCSD1 SMS SRPK2 SUMO3 TCF3 THAP12	67 interacting genes: AEBP1 ASCL3 AURKA BHLHA15 BHLHE40 CALM1 CALM3 CBFA2T3 CREBBP CTNNB1 DACH1 DAXX ELK3 EP300 FERD3L GLIS1 HAND1 HAND2 HOXA1 ID1 ID2 ID3 KAT2A KAT2B LMX1A LMX1B LYL1 MAPK1 MAPK3 MAPKAPK2 MAPKAPK3 MDFI MEN1 MSC MYF5 MYF6 MYOD1 MYOG NEDD9 NEUROD1 NHLH1 NSD3 PARP1 PDX1 PSMD4 PSMD9 RALGAPA1 RPL37 RUNX1T1 SCX SKP2 SRF SUPT3H TADA2A TAL1 TAL2 TCAF1 TCF12 TCF21 TCF4 TFPT TLE1 TRRAP TWIST1 TWIST2 UBE2I USF1
Entrez ID		7867	6929
HPRD ID		03678	00918
Ensembl ID		ENSG00000114738	ENSG00000071564
Uniprot IDs		A0A024R2W7 Q16644	A0A0A0MRB7 P15923 X6REB3
PDB IDs		3FHR 3FXW 3R1N 3SHE	1HLH 2MH0 2YPA 2YPB 3U5V 6MGN
Enriched GO Terms of Interacting Partners?
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