CACNA1B and PPM1A

Data Source:
HPRD (in vitro, in vivo)

		CACNA1B	PPM1A
Description		calcium voltage-gated channel subunit alpha1 B	protein phosphatase, Mg2+/Mn2+ dependent 1A
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GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Calcium Channel Complex Synapse	Nucleus Nucleoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Amyloid-beta Binding Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding Protein C-terminus Binding High Voltage-gated Calcium Channel Activity	Magnesium Ion Binding Protein Serine/threonine Phosphatase Activity Protein Binding Manganese Ion Binding Calmodulin-dependent Protein Phosphatase Activity R-SMAD Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Calcium Ion Transport Chemical Synaptic Transmission Regulation Of Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Membrane Depolarization Calcium Ion Import Calcium Ion Transmembrane Transport Response To Amyloid-beta	Negative Regulation Of Transcription By RNA Polymerase II Protein Dephosphorylation N-terminal Protein Myristoylation Cell Cycle Arrest Negative Regulation Of SMAD Protein Complex Assembly Dephosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Peptidyl-threonine Dephosphorylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Export From Nucleus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling
Pathways		Presynaptic depolarization and calcium channel opening	Downregulation of SMAD2/3:SMAD4 transcriptional activity Energy dependent regulation of mTOR by LKB1-AMPK
Drugs		Ergocalciferol Enflurane Amlodipine Amlodipine Spironolactone Verapamil Gabapentin Levetiracetam Seletracetam Contulakin-G Ziconotide Agmatine Benidipine Cilnidipine Butamben Bioallethrin
Diseases
GWAS		Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Bipolar disorder ( 31043756) Body mass index ( 28552196) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Parkinson's disease ( 32201043) Weight ( 28552196)	Allergic rhinitis ( 22036096) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Hair color ( 29662168) Hip circumference adjusted for BMI ( 25673412) Menarche (age at onset) ( 27182965) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		9 interacting genes: APBA1 CACNB3 GNAO1 GNB1 PDLIM5 PPM1A RGS12 RIMS1 RXRB	37 interacting genes: AATK AKT1 ALK CACNA1A CACNA1B CACNA1C CDC42BPA CDC42BPB CTNNB1 DVL1 DVL2 DVL3 EEF2 EGFR ERBB2 ERBB3 ERBB4 FGFR2 GRM3 HSPB1 IGF1R KDR LMTK2 MSN NR4A1 PAK1 PAK2 PIK3R1 PLK3 PRKAA1 PRKCA PRKCD PTK7 ROR2 RPLP0 SMAD2 SMAD3
Entrez ID		774	5494
HPRD ID		03005	16199
Ensembl ID		ENSG00000148408	ENSG00000100614
Uniprot IDs		Q00975	A0A024R6A5 B2R8E4 P35813
PDB IDs		2LCM	1A6Q 3FXJ 3FXK 3FXL 3FXM 3FXO 4RA2 4RAF 4RAG 6B67
Enriched GO Terms of Interacting Partners?
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