CACNA1B and RGS12

Data Source:
HPRD (in vivo)

		CACNA1B	RGS12
Description		calcium voltage-gated channel subunit alpha1 B	regulator of G protein signaling 12
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GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Calcium Channel Complex Synapse	Condensed Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Nuclear Matrix Dendrite Synapse
	Molecular Function	Amyloid-beta Binding Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding Protein C-terminus Binding High Voltage-gated Calcium Channel Activity	GTPase Activity GTPase Activator Activity Protein Binding GTPase Regulator Activity
	Biological Process	Calcium Ion Transport Chemical Synaptic Transmission Regulation Of Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Membrane Depolarization Calcium Ion Import Calcium Ion Transmembrane Transport Response To Amyloid-beta	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity
Pathways		Presynaptic depolarization and calcium channel opening	G alpha (i) signalling events G alpha (i) signalling events
Drugs		Ergocalciferol Enflurane Amlodipine Amlodipine Spironolactone Verapamil Gabapentin Levetiracetam Seletracetam Contulakin-G Ziconotide Agmatine Benidipine Cilnidipine Butamben Bioallethrin
Diseases
GWAS		Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Bipolar disorder ( 31043756) Body mass index ( 28552196) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Parkinson's disease ( 32201043) Weight ( 28552196)	Adult body size ( 32376654) Blood protein levels ( 28240269) Coronary artery disease ( 29212778) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 29403010) Hepatocyte growth factor levels ( 25998175) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Platelet count ( 29403010) Serum albumin level ( 29403010) Total cholesterol levels ( 29403010) Tuberculosis ( 29036319) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		9 interacting genes: APBA1 CACNB3 GNAO1 GNB1 PDLIM5 PPM1A RGS12 RIMS1 RXRB	17 interacting genes: ARAF CACNA1B CXCR2 EEF1A1 GNAI1 GNAI2 GNAI3 GRM2 GRM5 HRAS MAP2K2 MTNR1A NPY2R PLCB1 PLCB3 PM20D2 YWHAG
Entrez ID		774	6002
HPRD ID		03005	03943
Ensembl ID		ENSG00000148408	ENSG00000159788
Uniprot IDs		Q00975	O14924
PDB IDs		2LCM	2EBZ 2KV8
Enriched GO Terms of Interacting Partners?
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