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HDAC7 and HDAC2
Data Source:
BioGRID
(affinity chromatography technology, pull down)
HDAC7
HDAC2
Description
histone deacetylase 7
histone deacetylase 2
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Histone Deacetylase Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Sin3 Complex
NuRD Complex
Protein-containing Complex
ESC/E(Z) Complex
Molecular Function
Protein Kinase C Binding
Protein Binding
Protein Kinase Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Activating Transcription Factor Binding
Metal Ion Binding
Repressing Transcription Factor Binding
14-3-3 Protein Binding
RNA Polymerase II Repressing Transcription Factor Binding
Chromatin Binding
RNA Binding
Histone Deacetylase Activity
Protein Binding
Transcription Factor Binding
Deacetylase Activity
Enzyme Binding
Heat Shock Protein Binding
Nucleosomal DNA Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Histone Deacetylase Binding
Sequence-specific DNA Binding
NF-kappaB Binding
Promoter-specific Chromatin Binding
Biological Process
Protein Deacetylation
Negative Regulation Of Interleukin-2 Production
Negative Regulation Of Osteoblast Differentiation
Histone H3 Deacetylation
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Negative Regulation Of NIK/NF-kappaB Signaling
Negative Regulation Of Transcription By RNA Polymerase II
Response To Amphetamine
Cardiac Muscle Hypertrophy
Chromatin Remodeling
Blood Coagulation
Positive Regulation Of Cell Population Proliferation
Epidermal Cell Differentiation
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Neuron Projection Development
Dendrite Development
Histone Deacetylation
Response To Caffeine
Response To Lipopolysaccharide
Positive Regulation Of Interleukin-1 Production
Positive Regulation Of Tumor Necrosis Factor Production
Circadian Regulation Of Gene Expression
Positive Regulation Of Collagen Biosynthetic Process
Cellular Response To Heat
Response To Nicotine
Response To Cocaine
Odontogenesis Of Dentin-containing Tooth
Response To Drug
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Embryonic Digit Morphogenesis
ATP-dependent Chromatin Remodeling
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of MHC Class II Biosynthetic Process
Positive Regulation Of Proteolysis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Behavioral Response To Ethanol
Positive Regulation Of Oligodendrocyte Differentiation
Response To Hyperoxia
Hair Follicle Placode Formation
Negative Regulation Of Dendritic Spine Development
Eyelid Development In Camera-type Eye
Fungiform Papilla Formation
Cellular Response To Hydrogen Peroxide
Heterochromatin Maintenance
Histone H3 Deacetylation
Histone H4 Deacetylation
Cellular Response To Retinoic Acid
Cellular Response To Transforming Growth Factor Beta Stimulus
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Male Mating Behavior
Cellular Response To Dopamine
Positive Regulation Of Signaling Receptor Activity
Negative Regulation Of Peptidyl-lysine Acetylation
Pathways
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
SUMOylation of DNA damage response and repair proteins
Notch-HLH transcription pathway
Regulation of PTEN gene transcription
p75NTR negatively regulates cell cycle via SC1
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
SUMOylation of chromatin organization proteins
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
EGR2 and SOX10-mediated initiation of Schwann cell myelination
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Potential therapeutics for SARS
Factors involved in megakaryocyte development and platelet production
Drugs
Trichostatin A
Belinostat
Panobinostat
Pravastatin
Lovastatin
Theophylline
Valproic acid
Simvastatin
Atorvastatin
Fluvastatin
Aminophylline
Oxtriphylline
Vorinostat
Belinostat
Pracinostat
Romidepsin
Panobinostat
Tixocortol
Mocetinostat
Diseases
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
31361310
30929738
32296059
)
Asthma (adult onset) (
31036433
30929738
)
Bipolar disorder (
31043756
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) (
30940143
)
Conjunctival UV autofluorescence (CUVAF) (
25590795
)
Diastolic blood pressure (
27841878
)
Inflammatory bowel disease (
28067908
)
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean platelet volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Monocyte count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Obesity-related traits (
23251661
)
Platelet count (
32888494
27863252
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
27863252
)
Primary sclerosing cholangitis (
23603763
)
Systolic blood pressure (
27841878
)
Ulcerative colitis (
28067908
)
Urate levels (
23263486
)
White blood cell count (
32888494
)
Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy (
26460308
)
Metabolite levels (
23823483
)
Interacting Genes
59 interacting genes:
ACOT11
ACTN4
ANTKMT
ARID5A
BCL6
BRWD1
C3orf36
CALCOCO2
CASP8
CDC42
CENPQ
DDIT4L
EDNRA
EGFR
ESM1
GNG12
GNMT
GOLGA6L9
HDAC1
HDAC2
HDAC3
HDAC4
HDAC5
KAT5
KLF16
KRBA2
LDB2
MARK2
MARK3
MEF2A
MEF2C
MEOX2
MIEN1
NCOR2
NME4
NRIP2
PATJ
PHC2
PPARD
PPP1R16A
PRKD1
PRKD2
RAC1
RAC2
RAC3
REL
RIPPLY1
RRAS2
RUNX2
SIN3A
SLC16A3
SOGA1
TIAF1
UBE2I
UBL3
YPEL3
YWHAG
YWHAQ
ZBTB16
96 interacting genes:
ANTXR1
APPL1
ARID4A
AURKA
BCL11A
BRCA1
BRMS1
BRMS1L
BUB3
CDC20
CDH1
CDKN1A
CDYL
CHFR
CIR1
CSNK2A1
CSNK2A2
CTBP1
CYTOR
DAXX
DDX20
DMAP1
DNMT1
DNMT3B
EED
EID2
ERCC6
FKBP3
GATA3
H2AC1
H2AC20
H2BC21
H3-4
H3C1
HDAC1
HDAC10
HDAC7
HIF1A
HIF1AN
HOPX
HUWE1
IFRD1
IKZF1
IKZF4
ING1
MAD1L1
MBD2
MBD3L2
MEN1
MTA1
MXD1
NACC2
NRIP1
PA2G4
PADI4
PHB2
PHF21A
PIAS4
PML
PPARD
PPP1R8
PTMA
RBBP4
RBBP7
RBP1
RCOR1
RELA
RFX5
RUNX3
SALL1
SAP30
SETDB1
SIN3A
SMAD2
SMARCA5
SMYD1
SNW1
SP1
SP3
SPEN
SS18L1
STAT3
SUMO2
SUV39H1
SYK
TFCP2
THRA
THRB
TOP2A
TOP2B
TP53
USP4
VHL
YY1
ZBTB16
ZNF461
Entrez ID
51564
3066
HPRD ID
09133
05521
Ensembl ID
ENSG00000061273
ENSG00000196591
Uniprot IDs
Q8WUI4
Q92769
PDB IDs
3C0Y
3C0Z
3C10
3ZNR
3ZNS
3MAX
4LXZ
4LY1
5IWG
5IX0
6G3O
6WBW
6WBZ
6XDM
6XEB
6XEC
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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