HDAC7 and ACOT11

Data Source:
BioGRID (two hybrid)

		HDAC7	ACOT11
Description		histone deacetylase 7	acyl-CoA thioesterase 11
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol	Mitochondrial Matrix Cytosol Extracellular Exosome
	Molecular Function	Protein Kinase C Binding Protein Binding Protein Kinase Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Activating Transcription Factor Binding Metal Ion Binding Repressing Transcription Factor Binding 14-3-3 Protein Binding	Lipid Binding Palmitoyl-CoA Hydrolase Activity Long-chain Fatty Acyl-CoA Binding Acyl-CoA Hydrolase Activity Carboxylic Ester Hydrolase Activity Myristoyl-CoA Hydrolase Activity
	Biological Process	Protein Deacetylation Negative Regulation Of Interleukin-2 Production Negative Regulation Of Osteoblast Differentiation Histone H3 Deacetylation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of NIK/NF-kappaB Signaling	Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Response To Temperature Stimulus Response To Cold Intracellular Signal Transduction Negative Regulation Of Cold-induced Thermogenesis
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SUMOylation of DNA damage response and repair proteins Notch-HLH transcription pathway Regulation of PTEN gene transcription	Mitochondrial Fatty Acid Beta-Oxidation
Drugs		Trichostatin A Belinostat Panobinostat
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 30929738 32296059) Asthma (adult onset) ( 31036433 30929738) Bipolar disorder ( 31043756) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Conjunctival UV autofluorescence (CUVAF) ( 25590795) Diastolic blood pressure ( 27841878) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Primary sclerosing cholangitis ( 23603763) Systolic blood pressure ( 27841878) Ulcerative colitis ( 28067908) Urate levels ( 23263486) White blood cell count ( 32888494)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Epigenetic age acceleration in alcohol use disorder ( 31466081) Food allergy ( 25710614) Height ( 28552196) Rate of cognitive decline in mild cognitive impairment (time interaction) ( 22833209) Survival in pancreatic cancer ( 28470677)
Interacting Genes		59 interacting genes: ACOT11 ACTN4 ANTKMT ARID5A BCL6 BRWD1 C3orf36 CALCOCO2 CASP8 CDC42 CENPQ DDIT4L EDNRA EGFR ESM1 GNG12 GNMT GOLGA6L9 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 KAT5 KLF16 KRBA2 LDB2 MARK2 MARK3 MEF2A MEF2C MEOX2 MIEN1 NCOR2 NME4 NRIP2 PATJ PHC2 PPARD PPP1R16A PRKD1 PRKD2 RAC1 RAC2 RAC3 REL RIPPLY1 RRAS2 RUNX2 SIN3A SLC16A3 SOGA1 TIAF1 UBE2I UBL3 YPEL3 YWHAG YWHAQ ZBTB16	9 interacting genes: C2CD6 CABP5 EXOSC5 GEMIN6 HDAC7 HGS MAGEB4 MKRN3 SUOX
Entrez ID		51564	26027
HPRD ID		09133	07075
Ensembl ID		ENSG00000061273	ENSG00000162390
Uniprot IDs		Q8WUI4	Q8WXI4
PDB IDs		3C0Y 3C0Z 3C10 3ZNR 3ZNS	3FO5 6VVQ
Enriched GO Terms of Interacting Partners?
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