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SFN and LONRF1
Data Source:
BioGRID
(two hybrid)
SFN
LONRF1
Description
stratifin
LON peptidase N-terminal domain and ring finger 1
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Mitochondrion
Cytosol
Extracellular Exosome
Cytosol
Molecular Function
Protein Binding
Protein Kinase C Inhibitor Activity
Protein Kinase Binding
Identical Protein Binding
Cadherin Binding
Phosphoprotein Binding
Protein Binding
Metal Ion Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Release Of Cytochrome C From Mitochondria
Keratinocyte Development
Negative Regulation Of Protein Kinase Activity
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Epidermal Cell Division
Negative Regulation Of Keratinocyte Proliferation
Positive Regulation Of Cell Growth
Keratinization
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Epidermal Cell Differentiation
Positive Regulation Of Protein Export From Nucleus
Membrane Organization
Establishment Of Skin Barrier
Negative Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Protein Polyubiquitination
Pathways
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Regulation of localization of FOXO transcription factors
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Basophil percentage of granulocytes (
27863252
)
Basophil percentage of white cells (
27863252
)
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) (
30940143
)
Eosinophil percentage of white cells (
32888494
)
Neutrophil percentage of granulocytes (
27863252
)
Apolipoprotein A1 levels (
32203549
)
Colorectal cancer (diet interaction) (
24743840
)
HDL cholesterol levels (
32203549
)
Interacting Genes
56 interacting genes:
ABL1
ARAF
BAD
BAX
BCR
BRAF
CCAR1
CCDC102B
CCDC125
CCNH
CDC25B
CDK1
CHST1
COP1
DUXAP9
EEF1A1
EGFR
EIF2S1
EIF4B
EXO1
FAM189A2
FAM53C
FAM9B
FOXO1
FOXO4
GPRIN2
HDAC5
HNRNPD
ING1
KCNK15
KCNK3
KCNK9
KIAA0408
LNX2
LONRF1
MAGEA1
MAP3K5
MARK3
MDM4
MKRN3
MST1R
NR3C1
NTAQ1
PAX9
PLEKHF2
PLK4
RAB3IP
RFFL
SAMSN1
TBL3
TP53
TRIM25
TSC2
YWHAG
ZC2HC1C
ZFP36
96 interacting genes:
ADAMTSL4
ALAS1
AP2B1
ATG9A
AVPI1
BHLHB9
BRCA1
BYSL
C4orf17
CALCOCO2
CBLL2
CDKN2D
CFP
CRX
CYSRT1
DVL3
EFHC2
FLACC1
GABPB2
GORASP1
GORASP2
HLX
HOXA1
HSPB1
IHO1
IKZF2
IKZF3
IQCF2
KAT5
KATNBL1
KCTD21
KCTD9
KHDC1
KRT31
KRT35
KRT75
KRTAP1-3
KRTAP13-1
KRTAP13-3
KRTAP19-6
KRTAP19-7
KRTAP3-3
KRTAP6-1
LGALS9B
LHX2
LHX4
LNX1
MAGED1
MGAT5B
MID2
MRPL38
MTMR3
MYOZ3
NR4A1
NTAQ1
OOEP
PATZ1
PAX5
PAX6
PAX8
PICK1
PLSCR1
POU6F2
PPP1R3C
PRDM16
PRDM6
PRR35
PSMA1
RBPMS
RIMBP3C
RPRD1A
SFN
SLU7
SPRY2
STAU1
STX11
TASOR2
TBX19
TRAF2
TRIM27
TRIM42
TRIM8
TRIM9
UBE2I
UBE2L6
UCHL3
USP2
VGLL1
WDR83
XIAP
YPEL3
ZFP90
ZNF426
ZNF653
ZNF774
ZNHIT2
Entrez ID
2810
91694
HPRD ID
03185
08674
Ensembl ID
ENSG00000175793
ENSG00000154359
Uniprot IDs
P31947
Q17RB8
PDB IDs
1YWT
1YZ5
3IQJ
3IQU
3IQV
3LW1
3MHR
3O8I
3P1N
3P1O
3P1P
3P1Q
3P1R
3P1S
3SMK
3SML
3SMM
3SMN
3SMO
3SP5
3SPR
3T0L
3T0M
3U9X
3UX0
4DAT
4DAU
4DHM
4DHN
4DHO
4DHP
4DHQ
4DHR
4DHS
4DHT
4DHU
4FL5
4FR3
4IEA
4JC3
4JDD
4QLI
4Y32
4Y3B
4Y5I
5BTV
5HF3
5LTW
5LU1
5LU2
5MHC
5MOC
5MXO
5MY9
5MYC
5N5R
5N5T
5N5W
5N75
5OEG
5OEH
5OK9
5OKF
5OM0
5OMA
6FAU
6FAV
6FAW
6FBB
6FBW
6FBY
6FCP
6FI4
6FI5
6G6X
6G8I
6G8J
6G8K
6G8L
6G8P
6G8Q
6GHP
6HHP
6HKB
6HKF
6HMT
6HMU
6HN2
6NV2
6QDR
6QDS
6QDT
6QDU
6QHL
6QHM
6QIU
6QZR
6QZS
6R5L
6RHC
6RJL
6RJQ
6RJZ
6RK8
6RKI
6RKK
6RKM
6RL3
6RL4
6RL6
6RM5
6RM7
6RP6
6RWH
6RWI
6RWS
6RWU
6RX2
6S39
6S3C
6S40
6S9Q
6SIN
6SIO
6SIP
6SIQ
6SLV
6SLW
6SLX
6TCH
6TJM
6TL3
6TLF
6TLG
6TM7
6TWZ
6W0L
6XWD
6Y1J
6Y3M
6Y3O
6Y3R
6Y3S
6Y3V
6Y40
6Y44
6Y8A
6Y8B
6Y8D
6Y8E
6YOW
6YOX
6YOY
6YP2
6YP3
6YP8
6YPL
6YPY
6YQ2
7AEW
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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