SFN and MAP3K5

Data Source:
HPRD (two hybrid)

		SFN	MAP3K5
Description		stratifin	mitogen-activated protein kinase kinase kinase 5
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GO Annotations	Cellular Component	Extracellular Space Nucleus Mitochondrion Cytosol Extracellular Exosome	Cytoplasm Cytosol External Side Of Plasma Membrane Protein-containing Complex Protein Kinase Complex IRE1-TRAF2-ASK1 Complex
	Molecular Function	Protein Binding Protein Kinase C Inhibitor Activity Protein Kinase Binding Identical Protein Binding Cadherin Binding Phosphoprotein Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Release Of Cytochrome C From Mitochondria Keratinocyte Development Negative Regulation Of Protein Kinase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Epidermal Cell Division Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Cell Growth Keratinization Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Epidermal Cell Differentiation Positive Regulation Of Protein Export From Nucleus Membrane Organization Establishment Of Skin Barrier Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	MAPK Cascade Activation Of MAPKK Activity Response To Ischemia Protein Phosphorylation JNK Cascade Activation Of JUN Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Viral Process Cellular Response To Stress Cellular Response To Amino Acid Starvation Response To Endoplasmic Reticulum Stress P38MAPK Cascade Wound Healing Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of JUN Kinase Activity Innate Immune Response Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Stress-activated MAPK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Endothelial Cell Apoptotic Process Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of P38MAPK Cascade Positive Regulation Of Neuron Death Cellular Response To Reactive Nitrogen Species Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors	Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence
Drugs
Diseases
GWAS		Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Eosinophil percentage of white cells ( 32888494) Neutrophil percentage of granulocytes ( 27863252)	Eosinophil counts ( 32888494) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		56 interacting genes: ABL1 ARAF BAD BAX BCR BRAF CCAR1 CCDC102B CCDC125 CCNH CDC25B CDK1 CHST1 COP1 DUXAP9 EEF1A1 EGFR EIF2S1 EIF4B EXO1 FAM189A2 FAM53C FAM9B FOXO1 FOXO4 GPRIN2 HDAC5 HNRNPD ING1 KCNK15 KCNK3 KCNK9 KIAA0408 LNX2 LONRF1 MAGEA1 MAP3K5 MARK3 MDM4 MKRN3 MST1R NR3C1 NTAQ1 PAX9 PLEKHF2 PLK4 RAB3IP RFFL SAMSN1 TBL3 TP53 TRIM25 TSC2 YWHAG ZC2HC1C ZFP36	64 interacting genes: AKT1 ARRB1 ARRB2 AURKA CCND2 CDC25A CDK4 CDK6 CDKN1A CDKN2A CREBBP DAB2IP DAXX DMD DUSP19 EIF2AK2 EP300 ERN1 FGFR4 FZR1 GADD45B GEMIN5 GLIS2 GLRX GSTM1 HSPA1A IGF1R JAK2 MAP2K4 MAP2K6 MAP2K7 MAP3K2 MAP3K3 MAP3K6 MAP3K7 MAPK8IP3 MBP NEDD4 NEDD4L NF2 PDCD6 PPP3R1 PPP5C PTPN11 QARS1 RAF1 SFN SIAH1 STK11 TEAD2 TERT TNFAIP3 TNNT2 TPD52L1 TRAF2 TRAF5 TRAF6 TULP3 TXN USP9X YWHAE YWHAH YWHAQ YWHAZ
Entrez ID		2810	4217
HPRD ID		03185	03904
Ensembl ID		ENSG00000175793	ENSG00000197442
Uniprot IDs		P31947	Q99683
PDB IDs		1YWT 1YZ5 3IQJ 3IQU 3IQV 3LW1 3MHR 3O8I 3P1N 3P1O 3P1P 3P1Q 3P1R 3P1S 3SMK 3SML 3SMM 3SMN 3SMO 3SP5 3SPR 3T0L 3T0M 3U9X 3UX0 4DAT 4DAU 4DHM 4DHN 4DHO 4DHP 4DHQ 4DHR 4DHS 4DHT 4DHU 4FL5 4FR3 4IEA 4JC3 4JDD 4QLI 4Y32 4Y3B 4Y5I 5BTV 5HF3 5LTW 5LU1 5LU2 5MHC 5MOC 5MXO 5MY9 5MYC 5N5R 5N5T 5N5W 5N75 5OEG 5OEH 5OK9 5OKF 5OM0 5OMA 6FAU 6FAV 6FAW 6FBB 6FBW 6FBY 6FCP 6FI4 6FI5 6G6X 6G8I 6G8J 6G8K 6G8L 6G8P 6G8Q 6GHP 6HHP 6HKB 6HKF 6HMT 6HMU 6HN2 6NV2 6QDR 6QDS 6QDT 6QDU 6QHL 6QHM 6QIU 6QZR 6QZS 6R5L 6RHC 6RJL 6RJQ 6RJZ 6RK8 6RKI 6RKK 6RKM 6RL3 6RL4 6RL6 6RM5 6RM7 6RP6 6RWH 6RWI 6RWS 6RWU 6RX2 6S39 6S3C 6S40 6S9Q 6SIN 6SIO 6SIP 6SIQ 6SLV 6SLW 6SLX 6TCH 6TJM 6TL3 6TLF 6TLG 6TM7 6TWZ 6W0L 6XWD 6Y1J 6Y3M 6Y3O 6Y3R 6Y3S 6Y3V 6Y40 6Y44 6Y8A 6Y8B 6Y8D 6Y8E 6YOW 6YOX 6YOY 6YP2 6YP3 6YP8 6YPL 6YPY 6YQ2 7AEW	2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE 5ULM 5UOR 5UOX 5UP3 5V19 5V24 5VIL 5VIO 6E2M 6E2N 6E2O 6EJL 6OYT 6OYW 6VRE 6XIH
Enriched GO Terms of Interacting Partners?
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