XRCC4 and LIG4

Data Source:
HPRD (in vivo, in vitro)

		XRCC4	LIG4
Description		X-ray repair cross complementing 4	DNA ligase 4
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GO Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Site Of Double-strand Break Nonhomologous End Joining Complex	Chromosome, Telomeric Region Condensed Chromosome Nucleus Nucleoplasm DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Cytoplasmic Ribonucleoprotein Granule Nonhomologous End Joining Complex
	Molecular Function	DNA Binding Protein Binding Protein C-terminus Binding Ligase Activity Identical Protein Binding	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Protein C-terminus Binding Ligase Activity Metal Ion Binding
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Response To X-ray Immunoglobulin V(D)J Recombination DNA Ligation Involved In DNA Repair Positive Regulation Of Ligase Activity Cellular Response To Lithium Ion Establishment Of Integrated Proviral Latency Protein Localization To Site Of Double-strand Break	Single Strand Break Repair In Utero Embryonic Development Pro-B Cell Differentiation DNA Replication DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Central Nervous System Development Cell Population Proliferation Response To X-ray Response To Gamma Radiation T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Somatic Stem Cell Population Maintenance Negative Regulation Of Neuron Apoptotic Process Isotype Switching Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis DNA Ligation Involved In DNA Recombination DNA Ligation Involved In DNA Repair Chromosome Organization Cell Division Neuron Apoptotic Process Cellular Response To Lithium Ion Cellular Response To Ionizing Radiation DNA Biosynthetic Process Establishment Of Integrated Proviral Latency Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Chromosome Organization
Pathways		2-LTR circle formation SUMOylation of DNA damage response and repair proteins Nonhomologous End-Joining (NHEJ)	2-LTR circle formation Nonhomologous End-Joining (NHEJ)
Drugs		S-(Dimethylarsenic)Cysteine
Diseases			DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Clozapine-induced agranulocytosis ( 25187353) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Osteoarthritis biomarkers ( 25057126) Squamous cell lung carcinoma ( 28604730) Type 2 diabetes ( 25760438) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter integrity (fractional anisotropy) ( 29752348) White matter integrity (mean diffusivity) ( 29752348)	Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Irritable bowel syndrome ( 29626450)
Interacting Genes		23 interacting genes: ACTN1 AHNAK APLF APTX ASTE1 BIN1 CAAP1 CALM1 CHD3 CSNK2A1 FAM9B GSC2 GZMB HAUS2 IFFO1 KRT27 LIG4 MAGEA6 NBN NHEJ1 PNKP PRKDC VIM	103 interacting genes: ACTG1 AFTPH AGAP4 ALMS1 AMZ2P1 ANAPC10 APLF ASPM ATM ATP6V0D1 ATR B9D1 BBOF1 CAP1 CLU COL1A2 COMMD1 CPNE1 CREBBP CTSK DDX19A DGUOK DPP3 EIF2AK1 EIF3I EIF4A1 EIF4G3 ENO1 ETF1 FAM214A FBLL1 FIP1L1 GAPDH GGH GPANK1 GRHPR GUSBP3 GZMK HMGN1 HNRNPA2B1 IPP KDELR1 KIF3A LAP3 MAP2K2 MCM4 MCRS1 MRPS18C MT-CO1 MT-CO2 MT-CO3 MT-ND1 MT-ND4 MT-ND5 NDUFA13 NDUFB10 NEU1 NHEJ1 NOMO3 NPC2 OGFOD1 OSTM1 OXR1 PA2G4 PALLD PEX10 PGP PHF10 PMS2P1 PPIA PRKDC PSMA6 RBM5 RHBDD2 RPL11 RPS19BP1 RUVBL2 SEMA4G SMC2 SNX3 SOWAHC SRSF2 SYCP3 THOC5 TLE4 TOP1 TP53BP1 TPT1 TRAPPC3 TSFM UBB UBE2L3 UFSP2 UNC119 VKORC1 WARS1 WBP1L WDR20 XRCC4 ZFAND2A ZNF428 ZSCAN18 ZWINT
Entrez ID		7518	3981
HPRD ID		15951	03500
Ensembl ID		ENSG00000152422	ENSG00000174405
Uniprot IDs		A0A024RAL0 A0A024RAP0 A0A024RAQ8 Q13426 Q7Z763	A0A024RE06 A0A0C4DGV9 A8K8Q4 P49917
PDB IDs		1FU1 1IK9 3II6 3MUD 3Q4F 3RWR 3SR2 3W03 4XA4 5CHX 5CJ0 5CJ4 5E50 5WJ7 5WLZ 6ABO	1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP 6BKF 6BKG
Enriched GO Terms of Interacting Partners?
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