XRCC4 and NHEJ1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		XRCC4	NHEJ1
Description		X-ray repair cross complementing 4	non-homologous end joining factor 1
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GO Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Site Of Double-strand Break Nonhomologous End Joining Complex	Fibrillar Center Nucleus Nucleoplasm DNA Ligase IV Complex Nonhomologous End Joining Complex
	Molecular Function	DNA Binding Protein Binding Protein C-terminus Binding Ligase Activity Identical Protein Binding	Protein Binding DNA End Binding
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Response To X-ray Immunoglobulin V(D)J Recombination DNA Ligation Involved In DNA Repair Positive Regulation Of Ligase Activity Cellular Response To Lithium Ion Establishment Of Integrated Proviral Latency Protein Localization To Site Of Double-strand Break	Double-strand Break Repair Via Nonhomologous End Joining Central Nervous System Development Response To Ionizing Radiation B Cell Differentiation T Cell Differentiation Positive Regulation Of Ligase Activity
Pathways		2-LTR circle formation SUMOylation of DNA damage response and repair proteins Nonhomologous End-Joining (NHEJ)	Nonhomologous End-Joining (NHEJ)
Drugs		S-(Dimethylarsenic)Cysteine
Diseases			Severe combined immunodeficiency with microcephaly, growth retardation, and sensitivity to ionizing radiation; NHEJ1 syndrome
GWAS		Clozapine-induced agranulocytosis ( 25187353) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Osteoarthritis biomarkers ( 25057126) Squamous cell lung carcinoma ( 28604730) Type 2 diabetes ( 25760438) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter integrity (fractional anisotropy) ( 29752348) White matter integrity (mean diffusivity) ( 29752348)	Height ( 25282103 25429064 31562340) Serum polyunsaturated fatty acid concentration x sex interaction in metabolic syndrome ( 31991592) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		23 interacting genes: ACTN1 AHNAK APLF APTX ASTE1 BIN1 CAAP1 CALM1 CHD3 CSNK2A1 FAM9B GSC2 GZMB HAUS2 IFFO1 KRT27 LIG4 MAGEA6 NBN NHEJ1 PNKP PRKDC VIM	2 interacting genes: LIG4 XRCC4
Entrez ID		7518	79840
HPRD ID		15951	07784
Ensembl ID		ENSG00000152422	ENSG00000187736
Uniprot IDs		A0A024RAL0 A0A024RAP0 A0A024RAQ8 Q13426 Q7Z763	Q9H9Q4
PDB IDs		1FU1 1IK9 3II6 3MUD 3Q4F 3RWR 3SR2 3W03 4XA4 5CHX 5CJ0 5CJ4 5E50 5WJ7 5WLZ 6ABO	2QM4 2R9A 3Q4F 3RWR 3SR2 3W03 6ERG 6ERH
Enriched GO Terms of Interacting Partners?
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