Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
XBP1 and ATF6
Data Source:
BioGRID
(fluorescent resonance energy transfer, fluorescent resonance energy transfer)
XBP1
ATF6
Description
X-box binding protein 1
activating transcription factor 6
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Integral Component Of Membrane
Golgi Membrane
Chromatin
Nucleus
Nuclear Envelope
Nucleoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Heterodimerization Activity
Sequence-specific Double-stranded DNA Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
CAMP Response Element Binding
Identical Protein Binding
Sequence-specific DNA Binding
Protein Heterodimerization Activity
Sequence-specific Double-stranded DNA Binding
Biological Process
Angiogenesis
Liver Development
Positive Regulation Of Immunoglobulin Production
Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Fatty Acid Biosynthetic Process
Autophagy
Apoptotic Process
Immune Response
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response
Muscle Organ Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Myotube Differentiation
Protein Transport
Positive Regulation Of Cell Migration
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Nutrient
Positive Regulation Of Interleukin-6 Production
Cellular Response To Insulin Stimulus
Cellular Triglyceride Homeostasis
Positive Regulation Of Vascular Wound Healing
IRE1-mediated Unfolded Protein Response
ATF6-mediated Unfolded Protein Response
Cellular Response To Glucose Starvation
Cholesterol Homeostasis
Negative Regulation Of Apoptotic Process
Positive Regulation Of MHC Class II Biosynthetic Process
Positive Regulation Of B Cell Differentiation
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Fat Cell Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Neuron Development
Fatty Acid Homeostasis
Sterol Homeostasis
Adipose Tissue Development
Cellular Response To Lipopolysaccharide
Cellular Response To Amino Acid Stimulus
Cellular Response To Fructose Stimulus
Cellular Response To Glucose Stimulus
Cellular Response To Interleukin-4
Cellular Response To Peptide Hormone Stimulus
Positive Regulation Of Plasma Cell Differentiation
Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Lactation
Response To Insulin-like Growth Factor Stimulus
Positive Regulation Of Hepatocyte Proliferation
Eye Development
Regulation Of Transcription By RNA Polymerase II
Protein Folding
Signal Transduction
Visual Perception
Positive Regulation Of Autophagy
Endoplasmic Reticulum Unfolded Protein Response
ATF6-mediated Unfolded Protein Response
Positive Regulation Of Apoptotic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of ATF6-mediated Unfolded Protein Response
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
ATF6 (ATF6-alpha) activates chaperones
ATF6 (ATF6-alpha) activates chaperone genes
ATF6 (ATF6-alpha) activates chaperone genes
Drugs
Pseudoephedrine
Diseases
GWAS
Esophageal cancer (squamous cell) (
22960999
)
Esophageal squamous cell carcinoma (
25129146
)
Heel bone mineral density (
28869591
)
Mean arterial pressure (
29403010
)
Pancreatic cancer (
25086665
)
Chronic bronchitis in chronic obstructive pulmonary disease (
25241909
)
Parkinson's disease (age of onset) (
19772629
)
Systemic sclerosis (
30247649
)
Interacting Genes
22 interacting genes:
ATF6
ATF6B
CREBZF
ESR1
FOS
FUBP3
GLI1
H1-0
H1-10
HDGF
MDM2
MTNR1B
NR0B2
PCBD2
RBL2
SRSF1
SSX4
TRIP4
UBE2I
UBE2V1
ZNF440
ZNF580
15 interacting genes:
APP
ATF6B
BPGM
CREB1
CREB3L3
DAPK1
DDC
GTF2I
NFYA
NFYC
NNMT
SRF
TNFRSF1A
XBP1
YY1
Entrez ID
7494
22926
HPRD ID
01908
16118
Ensembl ID
ENSG00000100219
ENSG00000118217
Uniprot IDs
A0A024R1F0
P17861
A8K383
P18850
PDB IDs
6R5Q
6R6G
6R6P
6R7Q
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?