ATF6 and DDC

Data Source:
BioGRID (two hybrid)

		ATF6	DDC
Description		activating transcription factor 6	dopa decarboxylase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Integral Component Of Endoplasmic Reticulum Membrane	Cytoplasm Cytosol Synaptic Vesicle Axon Neuronal Cell Body Extracellular Exosome
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Identical Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Aromatic-L-amino-acid Decarboxylase Activity Protein Binding Amino Acid Binding Carboxy-lyase Activity Enzyme Binding Protein Domain Specific Binding Pyridoxal Phosphate Binding L-dopa Decarboxylase Activity
	Biological Process	Eye Development Regulation Of Transcription By RNA Polymerase II Protein Folding Signal Transduction Visual Perception Positive Regulation Of Autophagy Endoplasmic Reticulum Unfolded Protein Response ATF6-mediated Unfolded Protein Response Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Cellular Amino Acid Metabolic Process Catecholamine Metabolic Process Circadian Rhythm Multicellular Organism Aging Aminergic Neurotransmitter Loading Into Synaptic Vesicle Isoquinoline Alkaloid Metabolic Process Cellular Response To Drug Dopamine Biosynthetic Process Catecholamine Biosynthetic Process Serotonin Biosynthetic Process Indolalkylamine Biosynthetic Process Response To Pyrethroid Phytoalexin Metabolic Process Cellular Response To Alkaloid Cellular Response To Growth Factor Stimulus
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperones ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes	Catecholamine biosynthesis Serotonin and melatonin biosynthesis
Drugs		Pseudoephedrine	Pyridoxal phosphate Carbidopa Methyldopa Benserazide
Diseases
GWAS		Chronic bronchitis in chronic obstructive pulmonary disease ( 25241909) Parkinson's disease (age of onset) ( 19772629) Systemic sclerosis ( 30247649)	Acute lymphoblastic leukemia (childhood) ( 22076464 23512250 19684603) Adult body size ( 32376654) Blood metabolite ratios ( 24816252) Body mass index ( 26426971 25673413) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Chronotype ( 30696823) Malaria ( 19465909) Morning person ( 30696823) Schizophrenia (treatment resistant) ( 25223841)
Interacting Genes		15 interacting genes: APP ATF6B BPGM CREB1 CREB3L3 DAPK1 DDC GTF2I NFYA NFYC NNMT SRF TNFRSF1A XBP1 YY1	3 interacting genes: AR ATF6 RELA
Entrez ID		22926	1644
HPRD ID		16118	00145
Ensembl ID		ENSG00000118217	ENSG00000132437
Uniprot IDs		A8K383 P18850	A0A087WV24 A0A0S2Z3N4 P20711 Q53Y41
PDB IDs			3RBF 3RBL 3RCH
Enriched GO Terms of Interacting Partners?
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