XBP1 and SRSF1

Data Source:
BioGRID (two hybrid)

		XBP1	SRSF1
Description		X-box binding protein 1	serine and arginine rich splicing factor 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Exon-exon Junction Complex Catalytic Step 2 Spliceosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	RNA Binding MRNA Binding Protein Binding DNA Topoisomerase Binding
	Biological Process	Angiogenesis Liver Development Positive Regulation Of Immunoglobulin Production Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Fatty Acid Biosynthetic Process Autophagy Apoptotic Process Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Muscle Organ Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Myotube Differentiation Protein Transport Positive Regulation Of Cell Migration Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Nutrient Positive Regulation Of Interleukin-6 Production Cellular Response To Insulin Stimulus Cellular Triglyceride Homeostasis Positive Regulation Of Vascular Wound Healing IRE1-mediated Unfolded Protein Response ATF6-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Cholesterol Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Neuron Development Fatty Acid Homeostasis Sterol Homeostasis Adipose Tissue Development Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-4 Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Plasma Cell Differentiation Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lactation Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Hepatocyte Proliferation	Alternative MRNA Splicing, Via Spliceosome MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Splice Site Selection MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing
Pathways			Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs			Copper
Diseases
GWAS		Esophageal cancer (squamous cell) ( 22960999) Esophageal squamous cell carcinoma ( 25129146) Heel bone mineral density ( 28869591) Mean arterial pressure ( 29403010) Pancreatic cancer ( 25086665)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		22 interacting genes: ATF6 ATF6B CREBZF ESR1 FOS FUBP3 GLI1 H1-0 H1-10 HDGF MDM2 MTNR1B NR0B2 PCBD2 RBL2 SRSF1 SSX4 TRIP4 UBE2I UBE2V1 ZNF440 ZNF580	43 interacting genes: AKAP17A APP BCL10 C1QBP CACNA1A CD8A CDC42 CDK12 CDK6 CLK1 DIDO1 DYRK1A GEMIN2 HIPK3 HNRNPA0 LNX1 LUC7L3 NFYA NXF1 PPARG PRPF4 PRPF4B PSIP1 RNPS1 SCAF11 SNRNP70 SREK1 SRPK1 SRPK2 SRSF10 SRSF11 SRSF4 SRSF5 TCERG1 TNPO3 TOP1 TP53 TRA2B U2AF1 U2AF2 XBP1 YTHDC1 ZRSR2
Entrez ID		7494	6426
HPRD ID		01908	02887
Ensembl ID		ENSG00000100219	ENSG00000136450
Uniprot IDs		A0A024R1F0 P17861	Q07955 Q59FA2
PDB IDs		6R5Q 6R6G 6R6P 6R7Q	1X4A 2M7S 2M8D 2O3D 3BEG 4C0O
Enriched GO Terms of Interacting Partners?
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