ATF6 and GTF2I

Data Source:
HPRD (in vivo, in vitro)

		ATF6	GTF2I
Description		activating transcription factor 6	general transcription factor IIi
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Integral Component Of Endoplasmic Reticulum Membrane	Nucleus Nucleoplasm Cytoplasm Membrane
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Identical Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Eye Development Regulation Of Transcription By RNA Polymerase II Protein Folding Signal Transduction Visual Perception Positive Regulation Of Autophagy Endoplasmic Reticulum Unfolded Protein Response ATF6-mediated Unfolded Protein Response Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Negative Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA Repair By Transcription From RNA Polymerase II Promoter
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperones ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes
Drugs		Pseudoephedrine
Diseases
GWAS		Chronic bronchitis in chronic obstructive pulmonary disease ( 25241909) Parkinson's disease (age of onset) ( 19772629) Systemic sclerosis ( 30247649)	Atrial fibrillation ( 30061737 29892015) C-reactive protein levels ( 30388399) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Menarche (age at onset) ( 25231870) SjÃ¶gren's syndrome ( 24097066 27503288) Systemic lupus erythematosus ( 28714469)
Interacting Genes		15 interacting genes: APP ATF6B BPGM CREB1 CREB3L3 DAPK1 DDC GTF2I NFYA NFYC NNMT SRF TNFRSF1A XBP1 YY1	46 interacting genes: AP1B1 AP2B1 AP4S1 ATF6 BCL2L11 BTK C4BPA CALM1 CTAG1A CTAG1B DNMT3L DPY30 ERCC6 GCC1 HDAC3 JAK2 LINC01554 LSM8 MAP3K3 MAPK12 MAPK3 MTUS2 MYC NFKB2 PIAS2 PJA1 POU2AF1 PRKG1 PRRX1 SLU7 SMAD2 SNRPN SRC SRF STAT1 STAT3 SUMO2 TAB2 TRAF6 TRIM54 UBC UBE2I USF1 YY1 ZBTB17 ZMYM3
Entrez ID		22926	2969
HPRD ID		16118	03399
Ensembl ID		ENSG00000118217	ENSG00000263001
Uniprot IDs		A8K383 P18850	A8K9W7 P78347 Q499G6 X5D2J9 X5D939 X5DNP5 X5DR09
PDB IDs			2D9B 2DN4 2ED2 2EJE
Enriched GO Terms of Interacting Partners?
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