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IQGAP1 and PDLIM7
Data Source:
BioGRID
(two hybrid)
IQGAP1
PDLIM7
Description
IQ motif containing GTPase activating protein 1
PDZ and LIM domain 7
Image
GO Annotations
Cellular Component
Ruffle
Nucleus
Cytoplasm
Cytosol
Microtubule
Actin Filament
Plasma Membrane
Focal Adhesion
Actin Cytoskeleton
Microtubule Cytoskeleton
Axon
Growth Cone
Midbody
Secretory Granule Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Protein-containing Complex
Slit Diaphragm
Cytoplasmic Ribonucleoprotein Granule
Neuron Projection
Membrane Raft
Extracellular Exosome
Stress Fiber
Ruffle
Nucleoplasm
Cytosol
Adherens Junction
Focal Adhesion
Actin Cytoskeleton
Z Disc
Filamentous Actin
Molecular Function
MAP-kinase Scaffold Activity
GTPase Inhibitor Activity
GTPase Activator Activity
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Protein Kinase Binding
Protein Phosphatase Binding
Protein Domain Specific Binding
Small GTPase Binding
Protein Serine/threonine Kinase Activator Activity
S100 Protein Binding
Cadherin Binding
Actin Filament Binding
Mitogen-activated Protein Kinase Binding
Molecular Adaptor Activity
Actin Binding
Protein Binding
Metal Ion Binding
Muscle Alpha-actinin Binding
Biological Process
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Mitotic Cell Cycle
Viral Process
Cell Migration
Regulation Of Actin Cytoskeleton Organization
Negative Regulation Of GTPase Activity
Neutrophil Degranulation
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of GTPase Activity
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Focal Adhesion Assembly
Cellular Response To Calcium Ion
Cellular Response To Epidermal Growth Factor Stimulus
Glomerular Visceral Epithelial Cell Development
Positive Regulation Of Dendrite Development
Positive Regulation Of Peptidyl-tyrosine Autophosphorylation
Positive Regulation Of Cellular Protein Localization
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Neuron Projection Extension
Response To Angiotensin
Ossification
Receptor-mediated Endocytosis
Axon Guidance
Heart Development
Actin Cytoskeleton Organization
Positive Regulation Of Osteoblast Differentiation
Muscle Structure Development
Pathways
Nephrin family interactions
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
RHO GTPases activate IQGAPs
MAP2K and MAPK activation
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
RET signaling
Drugs
Artenimol
Diseases
GWAS
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic rhinitis (
31361310
)
Basophil count (
32888494
)
Basophil percentage of granulocytes (
27863252
)
Basophil percentage of white cells (
32888494
27863252
)
Chronic postoperative pain (
31903573
)
Heel bone mineral density (
30598549
)
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Male-pattern baldness (
28196072
)
Monocyte count (
32888494
)
Multiple sclerosis (
24076602
)
Neutrophil percentage of white cells (
32888494
)
Red cell distribution width (
32888494
)
Rheumatoid arthritis (
32868391
)
White blood cell count (basophil) (
27863252
)
Coronary artery disease (
29212778
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age <50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
38 interacting genes:
ACTA1
AIMP1
AKAP5
APC
CALM1
CDC42
CDH1
CLIC5
CLIP1
CTNNB1
CYBB
DUX4
EGFR
EZR
GRIA4
ILF2
KDR
LBX1
MAPK1
MEI4
MEN1
MEOX2
MYL1
NPHS1
OTX2
PDLIM7
PKNOX2
PRKACA
PTPRM
RAC1
S100B
STAU1
SUMO2
TEPSIN
TSG101
UBE2I
VASP
YWHAQ
62 interacting genes:
ABI2
AP5B1
BAG3
BSG
CATSPER1
CCDC185
DDX6
DGCR6
DNER
ENKD1
FAM214B
FAM71C
FAM90A1
FNDC11
FRS3
GEM
GFAP
GPATCH2L
HEY2
HNRNPD
HNRNPF
HSF2BP
HSPB7
IL16
IQGAP1
KANK2
MDM2
NUDT10
OTUD6A
PAK5
PARVG
PCBP1
PHF1
PIN1
PLEKHN1
PRKCA
PRKCB
PRKCZ
PRKD2
PSMF1
RASGEF1B
RET
RPP25
SCNM1
SH2B2
SH3BP2
SLAIN1
SMURF1
SPP1
TCF19
TNPO2
TP53
TPM2
TRAF2
TRAF3
TSG101
TSGA10IP
UBE2I
UBQLN4
WWP2
ZMYND11
ZNF165
Entrez ID
8826
9260
HPRD ID
04541
10436
Ensembl ID
ENSG00000140575
ENSG00000196923
Uniprot IDs
A0A024RC65
P46940
Q9NR12
PDB IDs
1X0H
2RR8
3FAY
3I6X
5L0O
2Q3G
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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