FAS and BTK

Data Source:
HPRD (in vivo)

		FAS	BTK
Description		Fas cell surface death receptor	Bruton tyrosine kinase
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GO Annotations	Cellular Component	Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Nuclear Body Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Membrane Raft Extracellular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Tumor Necrosis Factor-activated Receptor Activity Protein Binding Calmodulin Binding Kinase Binding Signaling Receptor Activity Identical Protein Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation-induced Cell Death Of T Cells Immune Response Signal Transduction Regulation Of Stress-activated MAPK Cascade Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amino Acid Starvation Fas Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Protein-containing Complex Assembly Cellular Response To Mechanical Stimulus Cellular Response To Hyperoxia Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Necroptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Type I Hypersensitivity Negative Regulation Of Cytokine Production Adaptive Immune Response B Cell Affinity Maturation Histamine Secretion By Mast Cell Regulation Of B Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of B Cell Apoptotic Process Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Mesoderm Development Peptidyl-tyrosine Phosphorylation Calcium-mediated Signaling Negative Regulation Of B Cell Proliferation Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway B Cell Activation Innate Immune Response Positive Regulation Of B Cell Differentiation Protein Autophosphorylation Cell Maturation B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Molecule Of Fungal Origin Apoptotic Signaling Pathway Cellular Response To Interleukin-7
Pathways		Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 FasL/ CD95L signaling	ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization G alpha (q) signalling events G alpha (12/13) signalling events MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) RHO GTPases Activate WASPs and WAVEs G beta:gamma signalling through BTK FCGR3A-mediated phagocytosis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Dasatinib Inositol 1,3,4,5-Tetrakisphosphate XL418 Ibrutinib Acalabrutinib Fostamatinib Zanubrutinib Abivertinib
Diseases		Hodgkin lymphoma Esophageal cancer Chronic lymphocytic leukemia (CLL) Adult T-cell leukemia	Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8 Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Ankylosing spondylitis ( 30946743) Atrioventricular conduction ( 21041692) Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Chronic lymphocytic leukemia ( 28165464 26956414 24292274 23770605) Immunoglobulin A ( 20694011) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Obesity-related traits ( 23251661) Red blood cell count ( 32888494) Selective IgA deficiency ( 27723758)
Interacting Genes		50 interacting genes: ANK3 APAF1 APOA5 ATP6V0B BAG6 BTK CALM1 CASP8 CASP8AP2 CCND3 CD47 CRMP1 DAXX DNAJC5 EEF1A1 EGFR ERG28 EZR FADD FAF1 FAF2 FAIM2 FASLG FBF1 FEM1B FYN GADD45A HIPK3 HNRNPC KRIT1 LCK LRIF1 MBD4 MET PDCD6 PRKCA PTPN13 PTPN6 RAP1A RIPK1 SUMO1 TCAP TMX1 TNFSF13 TRADD TRAF3 TRIP6 UBA7 UBE2I UBQLN1	76 interacting genes: ABL1 APP AR ARHGAP17 ARID3A ARRB1 AURKA BCL2L11 BECN1 BLNK BMX CAV1 CBL CD19 CMTM3 COASY DAPP1 ERBB3 EWSR1 FAS FASLG FYN GAB1 GNA12 GNAQ GNG2 GTF2I HCK IBTK IRAK1 ITK JAK1 KHDRBS1 KIT LYN MDM2 MEOX2 MET MRPS22 MYD88 PIK3AP1 PIK3R3 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PLAU PLCG1 PLCG2 PRKCA PRKCB PRKCE PRKCQ PRKCZ PRKD1 RELA RPS6KB1 RPS6KB2 SH2B2 SH3BP5 SMURF1 STAT5A SYK TEC TIRAP TLR4 TLR6 TLR8 TLR9 TNFRSF10A TP53 VAV1 WAS WASF2
Entrez ID		355	695
HPRD ID		00609	02248
Ensembl ID		ENSG00000026103	ENSG00000010671
Uniprot IDs		K9J972 P25445 Q59FU8	Q06187 Q5JY90
PDB IDs		1BZI 1DDF 2NA7 3EWT 3EZQ 3THM 3TJE	1AWW 1AWX 1B55 1BTK 1BWN 1K2P 1QLY 2GE9 2Z0P 3GEN 3K54 3OCS 3OCT 3P08 3PIX 3PIY 3PIZ 3PJ1 3PJ2 3PJ3 4NWM 4OT5 4OT6 4OTF 4OTQ 4OTR 4RFY 4RFZ 4RG0 4RX5 4YHF 4Z3V 4ZLY 4ZLZ 5BPY 5BQ0 5FBN 5FBO 5J87 5JRS 5KUP 5P9F 5P9G 5P9H 5P9I 5P9J 5P9K 5P9L 5P9M 5T18 5U9D 5VFI 5VGO 5XYZ 5ZZ4 6AUA 6AUB 6BIK 6BKE 6BKH 6BKW 6BLN 6DI0 6DI1 6DI3 6DI5 6DI9 6E4F 6EP9 6HRP 6HRT 6HTF 6J6M 6N9P 6NFH 6NFI 6NZM 6O8I 6OMU 6S90 6TFP 6X3N 6X3O 6X3P 6XE4
Enriched GO Terms of Interacting Partners?
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