VDAC2 and CYCS

Data Source:
HPRD (in vivo)

		VDAC2	CYCS
Description		voltage dependent anion channel 2	cytochrome c, somatic
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Mitochondrion Mitochondrial Outer Membrane Synaptic Vesicle Membrane Mitochondrial Membrane Mitochondrial Nucleoid Pore Complex	Protein Phosphatase Type 2A Complex Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Respirasome
	Molecular Function	Nucleotide Binding Protein Binding Voltage-gated Anion Channel Activity Porin Activity Cholesterol Binding Phosphatidylcholine Binding Ceramide Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Heme Binding Metal Ion Binding
	Biological Process	Anion Transport Binding Of Sperm To Zona Pellucida Inorganic Anion Transport Negative Regulation Of Protein Polymerization Mitochondrial Outer Membrane Permeabilization Anion Transmembrane Transport Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Mitochondrial Electron Transport, Cytochrome C To Oxygen Protein Dephosphorylation Apoptotic Process Mitochondrion Organization Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Cellular Response To Oxidative Stress Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Respiration
Pathways		Ub-specific processing proteases Mitochondrial calcium ion transport	Release of apoptotic factors from the mitochondria Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Respiratory electron transport Regulation of the apoptosome activity Regulation of the apoptosome activity
Drugs		Aluminium monostearate PRLX 93936	Minocycline Protoporphyrin Ix Containing Co Ferroheme C Imidazole Zinc protoporphyrin Trimethyllysine Zinc Substituted Heme C Artenimol
Diseases			Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS			Alzheimer's disease (cognitive decline) ( 23535033) High density lipoprotein cholesterol levels ( 30498476) Systemic lupus erythematosus ( 19838195)
Interacting Genes		11 interacting genes: ADRB2 APP BAK1 CYCS DUX4 DUX4L9 ECT2 HK1 NEDD4 NEDD4L RPS3A	22 interacting genes: AGTPBP1 APAF1 BCL2 BCL2L1 CASP9 COX4I2 CUL9 CYB5A CYB5R1 CYB5R3 CYC1 FDX1 HSPA8 HSPB1 KRT40 MEOX2 NDOR1 RNF7 SAFB SNCA UQCRC1 VDAC2
Entrez ID		7417	54205
HPRD ID		01904	00479
Ensembl ID		ENSG00000165637	ENSG00000172115
Uniprot IDs		A0A024QZT0 B4DKM5 P45880	G4XXL9 P99999
PDB IDs			1J3S 2N3Y 2N9I 2N9J 3NWV 3ZCF 3ZOO 5EXQ 5O10 5TY3 6DUJ 6ECJ
Enriched GO Terms of Interacting Partners?
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