VDAC2 and HK1

Data Source:
HPRD (in vitro)

		VDAC2	HK1
Description		voltage dependent anion channel 2	hexokinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Mitochondrion Mitochondrial Outer Membrane Synaptic Vesicle Membrane Mitochondrial Membrane Mitochondrial Nucleoid Pore Complex	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Raft
	Molecular Function	Nucleotide Binding Protein Binding Voltage-gated Anion Channel Activity Porin Activity Cholesterol Binding Phosphatidylcholine Binding Ceramide Binding	Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding Glucose Binding Fructokinase Activity Mannokinase Activity Identical Protein Binding Peptidoglycan Binding
	Biological Process	Anion Transport Binding Of Sperm To Zona Pellucida Inorganic Anion Transport Negative Regulation Of Protein Polymerization Mitochondrial Outer Membrane Permeabilization Anion Transmembrane Transport Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Cellular Glucose Homeostasis Positive Regulation Of Cytokine Production Involved In Immune Response Fructose 6-phosphate Metabolic Process Mannose Metabolic Process Glycolytic Process Inflammatory Response Positive Regulation Of Interleukin-1 Beta Production Innate Immune Response Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Canonical Glycolysis Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion
Pathways		Ub-specific processing proteases Mitochondrial calcium ion transport	Defective HK1 causes hexokinase deficiency (HK deficiency) Glycolysis
Drugs		Aluminium monostearate PRLX 93936	alpha-D-glucose 6-phosphate Beta-D-Glucose Phosphoaminophosphonic Acid-Adenylate Ester Lonidamine
Diseases			Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS			Apolipoprotein B levels ( 32203549) Birth weight ( 31043758) Glycated hemoglobin levels ( 20858683 31213470 19096518 28898252) Glycemic traits (pregnancy) ( 23903356) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494 27863252 19862010) Hemoglobin ( 32888494 19862010) Hemoglobin A1c levels ( 29844224 31217584) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693 28017375) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Iris color (a* coordinate) ( 29109912) Iris color (b* coordinate) ( 29109912) Ischemic stroke (cardioembolic) ( 29531354) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 32888494 20139978 27863252) Mean corpuscular volume ( 32888494 20139978 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Offspring birth weight ( 31043758) Plateletcrit ( 32888494) Red blood cell count ( 32888494 20139978 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		11 interacting genes: ADRB2 APP BAK1 CYCS DUX4 DUX4L9 ECT2 HK1 NEDD4 NEDD4L RPS3A	5 interacting genes: APP ENO2 SCMH1 VDAC1 VDAC2
Entrez ID		7417	3098
HPRD ID		01904	00809
Ensembl ID		ENSG00000165637	ENSG00000156515
Uniprot IDs		A0A024QZT0 B4DKM5 P45880	A0A024QZK7 A8K7J7 B3KXY9 P19367 P78542 Q59FD4
PDB IDs			1CZA 1DGK 1HKB 1HKC 1QHA 4F9O 4FOE 4FOI 4FPA 4FPB
Enriched GO Terms of Interacting Partners?
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