CYCS and CYB5R1

Data Source:
HPRD (in vitro)

		CYCS	CYB5R1
Description		cytochrome c, somatic	cytochrome b5 reductase 1
Image			No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Respirasome	Mitochondrion Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane Platelet Alpha Granule Membrane Extracellular Exosome
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Heme Binding Metal Ion Binding	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding FAD Binding
	Biological Process	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Mitochondrial Electron Transport, Cytochrome C To Oxygen Protein Dephosphorylation Apoptotic Process Mitochondrion Organization Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Cellular Response To Oxidative Stress Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Respiration	Platelet Degranulation Bicarbonate Transport Sterol Biosynthetic Process
Pathways		Release of apoptotic factors from the mitochondria Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Respiratory electron transport Regulation of the apoptosome activity Regulation of the apoptosome activity	Platelet degranulation Erythrocytes take up carbon dioxide and release oxygen
Drugs		Minocycline Protoporphyrin Ix Containing Co Ferroheme C Imidazole Zinc protoporphyrin Trimethyllysine Zinc Substituted Heme C Artenimol	Flavin adenine dinucleotide
Diseases		Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) High density lipoprotein cholesterol levels ( 30498476) Systemic lupus erythematosus ( 19838195)
Interacting Genes		22 interacting genes: AGTPBP1 APAF1 BCL2 BCL2L1 CASP9 COX4I2 CUL9 CYB5A CYB5R1 CYB5R3 CYC1 FDX1 HSPA8 HSPB1 KRT40 MEOX2 NDOR1 RNF7 SAFB SNCA UQCRC1 VDAC2	8 interacting genes: CYCS HIGD1C SGTA SGTB SLC51B TTC1 UBQLN1 UBQLN4
Entrez ID		54205	51706
HPRD ID		00479	06434
Ensembl ID		ENSG00000172115	ENSG00000159348
Uniprot IDs		G4XXL9 P99999	Q9UHQ9
PDB IDs		1J3S 2N3Y 2N9I 2N9J 3NWV 3ZCF 3ZOO 5EXQ 5O10 5TY3 6DUJ 6ECJ
Enriched GO Terms of Interacting Partners?
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